Basic Information
| Drug ID | DDPD00712 |
|
| Drug Name | Flurbiprofen | |
| Molecular Weight | 244.2609 | |
| Molecular Formula | C15H13FO2 | |
| CAS Number | 5104-49-4 | |
| SMILES | CC(C(O)=O)C1=CC(F)=C(C=C1)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00712 | |
| T3DB | T3D2866 | |
| PubChem Compound | 3394 | |
| PDR | 1118 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.16 | - | 4.16 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 110.5 | ℃ | 110-111 | ℃ | Adams, S.S., Bernard, J., Nicholson, J.S. and Blancafort, A.R.; U.S. Patent 3,755,427; Aug. 28, 1973; assigned to The Boots Company Ltd. |
| Water Solubility | 8.0 | mg/L | 8 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| Log S | -4.49 | - | -4.49 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | ~100 | % | PO, oral; | DRUGBANK |
| T Max | 2.3 | h | 0.5-4 | h | PO, oral; | DRUGBANK |
| Volume of Distribution | 14.0 | L | 14.0 | L | normal,healthy; adults; | DRUGBANK | Volume of Distribution | 12.0 | L | 12.0 | L | Arthritis; Geriatric; | DRUGBANK | Volume of Distribution | 10.0 | L | 10.0 | L | severe renal function; patients; | DRUGBANK | Volume of Distribution | 14.0 | L | 14.0 | L | Hepatitis, Hep; patients; | DRUGBANK | Volume of Distribution | 0.12 | L/kg | 0.12 | L/kg | DRUGBANK |
| Half-life | 4.7 | h | 4.7 | h | Optical rotation R; | DRUGBANK | Half-life | 5.7 | h | 5.7 | h | Optical rotation S; | DRUGBANK |
| Toxicity LD50 | 10.0 | mg/kg | 10.0 | mg/kg | PO, oral; dog; | DRUGBANK | Toxicity LD50 | 10.0 | mg/kg | 10.0 | mg/kg | PO, oral; dog; | T3DB |
| Eliminate Route | 70.0 | % | ~70 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 3.0 | % | <3 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Ocufen | flurbiprofen sodium | PDR |
| Max dose for adults | 100.0 | mg/dose | 100 | mg/dose | PO, oral | Ocufen | flurbiprofen sodium | PDR |
| Max dose for elderly | 300.0 | mg/day | 300 | mg/day | PO, oral | Ocufen | flurbiprofen sodium | PDR |
| Max dose for elderly | 100.0 | mg/dose | 100 | mg/dose | PO, oral | Ocufen | flurbiprofen sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1