Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00708 ...
Drug Name Sufentanil
Molecular Weight 386.551
Molecular Formula C22H30N2O2S
CAS Number 56030-54-7
SMILES CCC(=O)N(C1=CC=CC=C1)C1(COC)CCN(CCC2=CC=CS2)CC1
External Links
DRUGBANK DB00708
T3DB T3D2865
PubChem Compound 41693
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.95 - 3.95 - https://pubchem.ncbi.nlm.nih.gov/compound/sufentanil#section=Solubility
Melting Point 136.3 ℃ 136.3 ℃ MSDS
Log S -3.71 - -3.71 - https://pubchem.ncbi.nlm.nih.gov/compound/sufentanil#section=Solubility

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 52.0 % 52 % DRUGBANK
Bioavailability 35.0 % 35 % DRUGBANK
C Max 0.0750 ng/ml 0.05-0.1 ng/ml epidural administration; DRUGBANK
Clearance 55020.0 L/h 917.0 L/min Plasma clearance; intravenous injection, IV; Age ↑ ; DRUGBANK
Clearance 0.90 L/h/kg 15 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 14.0 L 14.0 L Total volume of distribution; DRUGBANK
Volume of Distribution 350.0 L ~350 L at steady state; DRUGBANK
Volume of Distribution 9.4 L/kg 9.4 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.7 h 164 min elimination half-life; intravenous injection, IV; adults; DRUGBANK
Half-life 1.6 h 97±42 min elimination half-life; Infants; Children; DRUGBANK
Half-life 7.2 h 434±160 min elimination half-life; Neonates; DRUGBANK
Half-life 8.0 h 6-10 h terminal half-life; DRUGBANK
Half-life 18.0 h 18 h terminal half-life; Multiple dose; DRUGBANK
Half-life 14.0 h 14 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 18.7 mg/kg 18.7 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 18.7 mg/kg 18.7 mg/kg intravenous injection, IV; mouse; T3DB
Eliminate Route 80.0 % ~80 % DRUGBANK
Eliminate Route 2.0 % 2 % Unchanged drug; DRUGBANK
Protein Binding 93.0 % 93 % plasma proteins; Male, men; normal,healthy; human, homo sapiens; DRUGBANK
Protein Binding 91.0 % 91 % plasma proteins;  Female, women; human, homo sapiens; DRUGBANK
Protein Binding 79.0 % 79 % plasma proteins; Neonates; human, homo sapiens; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1