Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00706 ...
Drug Name Tamsulosin
Molecular Weight 408.512
Molecular Formula C20H28N2O5S
CAS Number 106133-20-4
SMILES CCOC1=CC=CC=C1OCCN[C@H](C)CC1=CC(=C(OC)C=C1)S(N)(=O)=O
External Links
DRUGBANK DB00706
PubChem Compound 129211
PDR 2893
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 230.0 ℃ 230 ℃ FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 90.0 % 90 % PO, oral; fasting; DRUGBANK
AUC 175.0 ng.h/ml 151-199 ng.h/ml PO, oral; DRUGBANK
AUC 498.5 ng.h/ml 440-557 ng.h/ml PO, oral; DRUGBANK
Bioavailability 100.0 % 100.0 % PO, oral; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 4.2 ng/ml 3.1-5.3 ng/ml PO, oral; DRUGBANK
C Max 3.1 ng/ml 2.5-3.6 ng/ml PO, oral; DRUGBANK
C Max 16.0 ng/ml 16±5 ng/ml Oral single dose; extended release formulation; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 4.5 h 4-5 h PO, oral; fasting; DRUGBANK
T Max 6.5 h 6-7 h PO, oral; food; DRUGBANK
T Max 5.3 h 5.3±0.7 h Oral single dose; extended release formulation; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 2.9 L/h 2.88 L/h DRUGBANK
Clearance 0.0372 L/h/kg 0.62±0.31 ml/min/kg normal,healthy;  Female, women; hydrolysis; hydrolysis; Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.0372 L/h/kg 0.62 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 16.0 L 16.0 L intravenous injection, IV; DRUGBANK
Volume of Distribution 0.20 L/kg 0.20±0.06 L/kg normal,healthy;  Female, women; hydrolysis; hydrolysis; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.21 L/kg 0.21 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 14.9 h 14.9±3.9 h fasting; DRUGBANK
Half-life 6.0 h 5-7 h elimination half-life; normal,healthy; DRUGBANK
Half-life 11.0 h 9-13 h normal,healthy; DRUGBANK
Half-life 14.5 h 14-15 h patients; DRUGBANK
Half-life 6.8 h 6.8±3.5 h RD, renal impairment, Renal disease，including uremia ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 14.5 h ~14-15 h PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
Half-life 6.8 h 6.8 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 650.0 mg/kg 650.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 76.0 % 76 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 21.0 % 21 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 12.7 % 12.7±3 % Urinary excretion; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 96.5 % 94-99 % DRUGBANK
Protein Binding 99.0 % 99±1 % Male, men; normal,healthy; human, homo sapiens; RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 0.8 mg/day 0.8 mg/day PO, oral Flomax tamsulosin hydrochloride PDR
Max dose for elderly 0.8 mg/day 0.8 mg/day PO, oral Flomax tamsulosin hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1