Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00704 ...
Drug Name Naltrexone
Molecular Weight 341.4009
Molecular Formula C20H23NO4
CAS Number 16590-41-3
SMILES [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O
External Links
DRUGBANK DB00704
T3DB T3D2864
PubChem Compound 5360515
PDR 1199
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.92 - 1.92 - HANSCH,C ET AL. (1995)
Melting Point 169.0 ℃ 168-170 ℃ PhysProp
Water Solubility 100000.0 mg/L 100 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 22.5 % 5-40 % PO, oral; DRUGBANK
Clearance 210.0 L/h ~3.5 L/min intravenous injection, IV; DRUGBANK
Clearance 3.4 L/h/kg 57 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1350.0 L 1350.0 L intravenous injection, IV; DRUGBANK
Volume of Distribution 7.6 L/kg 7.6 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 4.0 h 4 h DRUGBANK
Half-life 13.0 h 13 h DRUGBANK
Half-life 1.9 h 1.9 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1325.0 mg/kg 1100-1550 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 1450.0 mg/kg 1450.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1490.0 mg/kg 1490.0 mg/kg PO, oral; guinea pigs; DRUGBANK
Toxicity LD50 1325.0 mg/kg 1100-1550 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 1450.0 mg/kg 1450.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 1490.0 mg/kg 1490.0 mg/kg PO, oral; guinea pigs; T3DB
Eliminate Route 66.0 % 53-79 % Urinary excretion; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Protein Binding 21.0 % 21 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 150.0 mg/day 150 mg/day PO, oral Vivitrol naltrexone PDR
Max dose for adults 380.0 mg/dose 380 mg/dose IM,intramuscular injection Vivitrol naltrexone PDR
Max dose for elderly 150.0 mg/day 150 mg/day PO, oral Vivitrol naltrexone PDR
Max dose for elderly 380.0 mg/dose 380 mg/dose IM,intramuscular injection Vivitrol naltrexone PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1