Basic Information
| Drug ID | DDPD00700 |
|
| Drug Name | Eplerenone | |
| Molecular Weight | 414.4914 | |
| Molecular Formula | C24H30O6 | |
| CAS Number | 107724-20-9 | |
| SMILES | [H][C@@]12CC[C@@]3(CCC(=O)O3)[C@@]1(C)C[C@H]1O[C@@]11[C@@]2([H])[C@@H](CC2=CC(=O)CC[C@]12C)C(=O)OC | |
| External Links | ||
| DRUGBANK | DB00700 | |
| PubChem Compound | 443872 | |
| PDR | 1817 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.3 | - | 1.3 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 1000.0 | ng/ml | 1.0±0.3 | mcg/ml | PO, oral; | The Pharmacological Basis of Therapeutics | |
| T Max | 1.8 | h | 1.8±0.7 | h | PO, oral; | The Pharmacological Basis of Therapeutics | |
| Clearance | 10.0 | L/h | 10.0 | L/h | Plasma clearance; | DRUGBANK | Clearance | 0.14 | L/h/kg | 2.4 | ml/min/kg | hepatopathy，LD ↓ ;congestive heart disease ↓ ; | The Pharmacological Basis of Therapeutics |
| Volume of Distribution | 66.5 | L | 43-90 | L | DRUGBANK | Volume of Distribution | 0.95 | L/kg | 0.6-1.3 | L/kg | The Pharmacological Basis of Therapeutics |
| Half-life | 5.0 | h | 4-6 | h | DRUGBANK | Half-life | 5.0 | h | 4-6 | h | The Pharmacological Basis of Therapeutics |
| Eliminate Route | 7.0 | % | 7 | % | Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
| Protein Binding | 50.0 | % | 50 | % | DRUGBANK | Protein Binding | 46.5 | % | 33-60 | % | normal,healthy; human, homo sapiens; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Inspra | eplerenone | PDR |
| Max dose for adults | 50.0 | mg/day | 50 | mg/day | PO, oral | Inspra | eplerenone | PDR |
| Max dose for elderly | 100.0 | mg/day | 100 | mg/day | PO, oral | Inspra | eplerenone | PDR |
| Max dose for elderly | 50.0 | mg/day | 50 | mg/day | PO, oral | Inspra | eplerenone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1