Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00698 ...
Drug Name Nitrofurantoin
Molecular Weight 238.159
Molecular Formula C8H6N4O5
CAS Number 67-20-9
SMILES [O-][N+](=O)C1=CC=C(O1)\C=N\N1CC(=O)NC1=O
External Links
DRUGBANK DB00698
T3DB T3D2679
PubChem Compound 6604200
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.47 - -0.47 - HANSCH,C ET AL. (1995)
Melting Point 225.5 ℃ 223-228 ℃ Gever, G.; U.S. Patent 2,802,002; August 6, 1957; assigned to The Norwich Pharmacal Co.
Water Solubility 79.5 mg/L 79.5 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
pKa 7.2 - 7.2 - SANGSTER (1994)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 2315.0 ng.h/ml 2.21-2.42 mg.h/l DRUGBANK
Bioavailability 41.6 % 38.8-44.3 % DRUGBANK
Bioavailability 87.0 % 87±13 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 919.0 ng/ml 0.875-0.963 mg/L DRUGBANK
C Max 428.0 ng/ml 428±146 ng/ml fasting; adults; normal,healthy; food → ; The Pharmacological Basis of Therapeutics
T Max 2.3 h 2.3±1.4 h fasting; adults; normal,healthy; food → ; The Pharmacological Basis of Therapeutics
Metabolic 1.3 % 0.8-1.8 % DRUGBANK
Clearance 18.1 L/h 16.7-19.4 L/h DRUGBANK
Clearance 0.59 L/h/kg 9.9±0.9 ml/min/kg normal,healthy; adults; Urine alkaline ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.58 L/h/kg 9.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.46 L/kg 0.46 L/kg dog; DRUGBANK
Volume of Distribution 0.58 L/kg 0.58±0.12 L/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.57 L/kg 0.57 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.75 h 0.72-0.78 h DRUGBANK
Half-life 1.0 h 1.0±0.2 h Urine alkaline → ; The Pharmacological Basis of Therapeutics
Half-life 0.97 h 0.97 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 90.0 % 90 % Urinary excretion; DRUGBANK
Eliminate Route 38.5 % 27-50 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 47.0 % 47±13 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 90.0 % ~90 % plasma proteins; DRUGBANK
Protein Binding 62.0 % 62±4 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1