Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00694 ...
Drug Name Daunorubicin
Molecular Weight 527.5199
Molecular Formula C27H29NO10
CAS Number 20830-81-3
SMILES COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C(C)=O)C(O)=C1C2=O
External Links
DRUGBANK DB00694
T3DB T3D2861
PubChem Compound 30323
PDR 1553
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.83 - 1.83 - SANGSTER (1993)
Melting Point 208.5 ℃ 208-209 ℃ PhysProp
Water Solubility 39.2 mg/L 39.2 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 2.9 L/h/kg 47.57 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 32.1 L/kg 32.05 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 18.5 h 18.5 h DRUGBANK
Half-life 14.2 h 14.24 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 20.0 mg/kg 20.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 13.0 mg/kg 13.0 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Toxicity LD50 20.0 mg/kg 20.0 mg/kg intravenous injection, IV; mouse; T3DB
Toxicity LD50 13.0 mg/kg 13.0 mg/kg intravenous injection, IV; Rattus, Rat; T3DB
Eliminate Route 25.0 % 25 % Urinary excretion; DRUGBANK
Eliminate Route 40.0 % 40 % Bile excretion; DRUGBANK
Protein Binding 97.0 % 97 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 0.142857142857143 mg/kg/day 1 mg/kg/week intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for infants 10.0 mg/kg/dose 10 mg/kg/dose intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for children 25.0 mg/m2 25 mg/m2 Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for children 300.0 mg/m2 300 mg/m2 intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for children 0.14285714 mg/kg/day 1 mg/kg/week intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for children 10.0 mg/kg/dose 10 mg/kg/dose intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for adolescents 25.0 mg/m2/day 25 mg/m2/day intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for adolescents 300.0 mg/m2 300 mg/m2 intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for adults 45.0 mg/m2 45 mg/m2 intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for adults 90.0 mg/m2 90 mg/m2 intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for adults 500.0 mg/m2 500 mg/m2 Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for adults 400.0 mg/m2 400 mg/m2 Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for geriatric 45.0 mg/m2 45 mg/m2 intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for geriatric 90.0 mg/m2 90 mg/m2 intravenous injection, IV Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for geriatric 500.0 mg/m2 500 mg/m2 Daunorubicin Hydrochloride daunorubicin hydrochloride PDR
Max dose for geriatric 400.0 mg/m2 400 mg/m2 Daunorubicin Hydrochloride daunorubicin hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1