Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00685 ...
Drug Name Trovafloxacin
Molecular Weight 416.36
Molecular Formula C20H15F3N4O3
CAS Number 147059-72-1
SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2N)C1=NC2=C(C=C1F)C(=O)C(=CN2C1=C(F)C=C(F)C=C1)C(O)=O
External Links
DRUGBANK DB00685
PubChem Compound 62959
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.31 - 0.31 - DAYLIGHT (2002)
Water Solubility 12.3 mg/L 12.3 mg/L MCFARLAND,JW ET AL. 2001)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 88.0 % 88 % PO, oral; food; food → ; DRUGBANK
Metabolic 13.0 % 13 % Urinary excretion; DRUGBANK
Metabolic 9.0 % 9 % Faeces excretion; DRUGBANK
Clearance 0.0840 L/h/kg 1.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.3 L/kg 1.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 10.7 h 9.1-12.2 h PO, oral; DRUGBANK
Half-life 11.1 h 9.4-12.7 h intravenous injection, IV; DRUGBANK
Half-life 11.0 h 11 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 43.0 % 43 % Faeces excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 6.0 % 6 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Protein Binding 76.0 % ~76 % plasma proteins; Plasma Concentration → ; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1