Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00684 ...
Drug Name Tobramycin
Molecular Weight 467.5145
Molecular Formula C18H37N5O9
CAS Number 32986-56-4
SMILES NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
External Links
DRUGBANK DB00684
PubChem Compound 36294
PDR 1105
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -5.8 - -5.8 - DRUGBANK
Water Solubility 1000000.0 mg/L 1000 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 0.0960 L/h/kg 1.6 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.23 L/kg 0.23 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h ~2 h elimination half-life; intravenous injection, IV; DRUGBANK
Half-life 2.0 h 2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 441.0 mg/kg 441.0 mg/kg subcutaneous injection, SC; mouse; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for neonates 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for infants 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for infants 48.0 drop/day 48 drop/day ophthalmic administration Tobrex Ophthalmic Solution tobramycin PDR
Max dose for infants 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for children 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for children 48.0 drop/day 48 drop/day ophthalmic administration Tobrex Ophthalmic Solution tobramycin PDR
Max dose for children 600.0 mg/day 600 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR
Max dose for children 224.0 mg/day 224 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR
Max dose for children 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for children 48.0 drop/day 48 drop/day ophthalmic administration Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adolescents 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adolescents 48.0 drop/day 48 drop/day ophthalmic administration Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adolescents 600.0 mg/day 600 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adolescents 224.0 mg/day 224 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adults 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adults 48.0 drop/day 48 drop/day ophthalmic administration Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adults 600.0 mg/day 600 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR
Max dose for adults 224.0 mg/day 224 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR
Max dose for geriatric 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Tobrex Ophthalmic Solution tobramycin PDR
Max dose for geriatric 48.0 drop/day 48 drop/day ophthalmic administration Tobrex Ophthalmic Solution tobramycin PDR
Max dose for geriatric 600.0 mg/day 600 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR
Max dose for geriatric 224.0 mg/day 224 mg/day inhalation, IH Tobrex Ophthalmic Solution tobramycin PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1