Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00682 ...
Drug Name Warfarin
Molecular Weight 308.3279
Molecular Formula C19H16O4
CAS Number 81-81-2
SMILES CC(=O)CC(C1=CC=CC=C1)C1=C(O)C2=C(OC1=O)C=CC=C2
External Links
DRUGBANK DB00682
T3DB T3D2567
PubChem Compound 54678486
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -4.68 - -4.68 - ADME Research, USCD
Log P 2.7 - 2.7 - HANSCH,C ET AL. (1995)
Melting Point 161.0 ℃ 161 ℃ PhysProp
Water Solubility 17.0 mg/L 17 mg/L TOMLIN,C 1997)
pKa 5.0 - 5 - UFER, M (2005)
Log S -3.89 - -3.89 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % 100 % Tablet, PO, oral; DRUGBANK
Bioavailability 93.0 % 93±8 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 900.0 ng/ml 0.9±0.4 mcg/ml PO, oral; Optical rotation R; patients; The Pharmacological Basis of Therapeutics
C Max 500.0 ng/ml 0.5±0.2 mcg/ml PO, oral; Optical rotation S; patients; The Pharmacological Basis of Therapeutics
T Max 4.0 h 4 h Tablet, PO, oral; DRUGBANK
T Max 4.0 h <4 h PO, oral; patients; The Pharmacological Basis of Therapeutics
Clearance 0.002550 L/h/kg 0.020-0.065 ml/min/kg DRUGBANK
Clearance 0.002700 L/h/kg 0.045±0.024 ml/min/kg Elderly → ;acute viral hepatitis AVH → ;Cystic fibrosis → ; The Pharmacological Basis of Therapeutics
Clearance 0.003300 L/h/kg 0.055 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.14 L/kg 0.14 L/kg DRUGBANK
Volume of Distribution 0.14 L/kg 0.14±0.06 L/kg Elderly → ;acute viral hepatitis AVH → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.13 L/kg 0.13 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 63.0 h 37-89 h Optical rotation R; DRUGBANK
Half-life 32.0 h 21-43 h Optical rotation S; DRUGBANK
Half-life 37.0 h 37±15 h acute viral hepatitis AVH → ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 43.0 h 43±14 h Optical rotation R; The Pharmacological Basis of Therapeutics
Half-life 32.0 h 32±12 h Optical rotation S; The Pharmacological Basis of Therapeutics
Half-life 29.0 h 29 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 3.0 mg/kg 3.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 165.0 mg/kg 165.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 750.0 mg/kg 750.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Toxicity LD50 1.6 mg/kg 1.6 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 320.0 mg/kg 320.0 mg/kg inhalation, IH; Rattus, Rat; DRUGBANK
Toxicity LD50 1400.0 mg/kg 1400.0 mg/kg skin/dermal; Rattus, Rat; DRUGBANK
Toxicity LD50 800.0 mg/kg 800.0 mg/kg PO, oral; rabbit; DRUGBANK
Toxicity LD50 1.0 mg/kg 1.0 mg/kg PO, oral; pig; DRUGBANK
Toxicity LD50 3.0 mg/kg 3.0 mg/kg PO, oral; dog; DRUGBANK
Toxicity LD50 6.0 mg/kg 6.0 mg/kg PO, oral; cat; DRUGBANK
Toxicity LD50 942.0 mg/kg 942.0 mg/kg PO, oral; chicken; DRUGBANK
Toxicity LD50 180.0 mg/kg 180.0 mg/kg PO, oral; guinea pigs; DRUGBANK
Toxicity LD50 374.0 mg/kg 374.0 mg/kg PO, oral; mouse; T3DB
Toxicity Lethal Dose 6.7 mg/kg 6667.0 ug/kg human, homo sapiens; T3DB
Eliminate Route 80.0 % 80 % Urinary excretion; DRUGBANK
Eliminate Route 20.0 % 20 % Faeces excretion; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; Raceme D/L; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.0 % 99 % DRUGBANK
Protein Binding 99.0 % 99±1 % Preg, pregnant → ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1