Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00681 ...
Drug Name Amphotericin B
Molecular Weight 924.079
Molecular Formula C47H73NO17
CAS Number 1397-89-3
SMILES [H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2
External Links
DRUGBANK DB00681
PubChem Compound 5280965
PDR 1330
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.8 - 0.8 - DRUGBANK
Melting Point 170.0 ℃ 170 ℃ DRUGBANK
Water Solubility 750.0 mg/L 750 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 100.0 % 100 % intravenous injection, IV; DRUGBANK
Bioavailability 5.0 % <5 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1200.0 ng/ml 1.2±0.33 mcg/ml intravenous infusion, IV in drop; The Pharmacological Basis of Therapeutics
C Max 1700.0 ng/ml 1.7±0.8 ug/ml intravenous infusion, IV in drop; Drug form; The Pharmacological Basis of Therapeutics
C Max 83000.0 ng/ml 83±35 ug/ml intravenous infusion, IV in drop; Drug form; The Pharmacological Basis of Therapeutics
Clearance 0.0390 L/h/kg 39±22 ml/h/kg intravenous infusion, IV in drop; febrile neutropenic cancer; bone marrow transplant; DRUGBANK
Clearance 0.0170 L/h/kg 17±6 ml/h/kg intravenous infusion, IV in drop; febrile neutropenic cancer; bone marrow transplant; DRUGBANK
Clearance 0.0510 L/h/kg 51±44 ml/h/kg intravenous infusion, IV in drop; febrile neutropenic cancer; bone marrow transplant; DRUGBANK
Clearance 0.0220 L/h/kg 22±15 ml/h/kg intravenous infusion, IV in drop; febrile neutropenic cancer; bone marrow transplant; DRUGBANK
Clearance 0.0210 L/h/kg 21±14 ml/h/kg intravenous infusion, IV in drop; febrile neutropenic cancer; bone marrow transplant; DRUGBANK
Clearance 0.0110 L/h/kg 11±6 ml/h/kg intravenous infusion, IV in drop; febrile neutropenic cancer; bone marrow transplant; DRUGBANK
Clearance 0.0276 L/h/kg 0.46±0.20 ml/min/kg Children; Prem, premature → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.0102 L/h/kg 0.17 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.76 L/kg 0.76±0.52 L/kg Total volume of distribution; increasing doses ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.62 L/kg 0.62 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 360.0 h ~15 day elimination half-life; DRUGBANK
Half-life 24.0 h ~24 h elimination half-life; DRUGBANK
Half-life 18.0 h 18±7 h Multiple dose; The Pharmacological Basis of Therapeutics
Half-life 40.0 h 40 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 5000.0 mg/kg >5 g/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 3.5 % 2-5 % Urinary excretion; Capsule, PO, Oral; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 90.0 % 90 % plasma proteins; DRUGBANK
Protein Binding 90.0 % >90 % Capsule, PO, Oral; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 7.0 mg/kg/day 7 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for infants 6.0 mg/kg/day 6 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for children 6.0 mg/kg/day 6 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for adolescents 6.0 mg/kg/day 6 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for adults 6.0 mg/kg/day 6 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for adults 15.0 mg/kg/day 15 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for geriatric 6.0 mg/kg/day 6 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for geriatric 15.0 mg/kg/day 15 mg/kg/day intravenous injection, IV AmBisome amphotericin B liposome PDR
Max dose for children 1.25 mg/kg/day 1.25 mg/kg/day intravenous injection, IV Amphotericin B amphotericin B PDR
Max dose for adolescents 1.25 mg/kg/day 1.25 mg/kg/day intravenous injection, IV Amphotericin B amphotericin B PDR
Max dose for elderly 1.25 mg/kg/day 1.25 mg/kg/day intravenous injection, IV Amphotericin B amphotericin B PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1