Basic Information
| Drug ID | DDPD00679 |
|
| Drug Name | Thioridazine | |
| Molecular Weight | 370.575 | |
| Molecular Formula | C21H26N2S2 | |
| CAS Number | 50-52-2 | |
| SMILES | CSC1=CC2=C(SC3=CC=CC=C3N2CCC2CCCCN2C)C=C1 | |
| External Links | ||
| DRUGBANK | DB00679 | |
| T3DB | T3D2858 | |
| PubChem Compound | 5452 | |
| PDR | 2296 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.9 | - | 5.9 | - | HANSCH,C ET AL. (1995) |
| Boiling Point | 230.0 | ℃ | 230 | ℃ | PhysProp |
| Melting Point | 73.0 | ℃ | 73 | ℃ | PhysProp |
| Water Solubility | 0.0336 | mg/L | 0.0336 | mg/L | DRUGBANK |
| pKa | 9.5 | - | 9.5 | - | EL TAYAR,N ET AL. (1985) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 60.0 | % | 60 | % | DRUGBANK | |
| Half-life | 23.0 | h | 21-25 | h | DRUGBANK | |
| Toxicity LD50 | 995.0 | mg/kg | 956-1034 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 995.0 | mg/kg | 956-1034 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Protein Binding | 95.0 | % | 95 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 3.0 | mg/kg/day | 3 | mg/kg/day | PO, oral | Thioridazine Hydrochloride | thioridazine hydrochloride | PDR |
| Max dose for adults | 800.0 | mg/day | 800 | mg/day | PO, oral | Thioridazine Hydrochloride | thioridazine hydrochloride | PDR |
| Max dose for geriatric | 800.0 | mg/day | 800 | mg/day | PO, oral | Thioridazine Hydrochloride | thioridazine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1