| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Factor |
Reference |
| Bioavailability |
95.0 |
% |
90-100 |
% |
PO, oral; |
|
DRUGBANK |
Bioavailability |
100.0 |
% |
100(91-110) |
% |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
| C Max |
96.0 |
ng/ml |
96±29 |
ng/ml |
PO, oral; Elderly; normal,healthy; |
|
The Pharmacological Basis of Therapeutics |
| T Max |
1.0 |
h |
1 |
h |
PO, oral; |
|
DRUGBANK |
T Max |
2.6 |
h |
2.6±1.0 |
h |
PO, oral; Elderly; normal,healthy; |
|
The Pharmacological Basis of Therapeutics |
| Metabolic |
75.0 |
% |
75 |
% |
|
|
DRUGBANK |
| Clearance |
3.9 |
L/h |
~65 |
ml/min |
Renal clearance; |
|
DRUGBANK |
Clearance |
18.0 |
L/h |
~300 |
ml/min |
Plasma clearance; |
|
DRUGBANK |
Clearance |
0.34 |
L/h/kg |
5.7(5.0-6.3) |
ml/min/kg |
hydrolysis; hydrolysis; metabolism of ugt; |
hepatopathy，LD ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; |
The Pharmacological Basis of Therapeutics |
| Volume of Distribution |
175.0 |
L |
175.0 |
L |
Average volume of distribution; |
|
DRUGBANK |
Volume of Distribution |
2.6 |
L/kg |
2.6(2.4-2.9) |
L/kg |
|
|
The Pharmacological Basis of Therapeutics |
| Half-life |
7.0 |
h |
~7 |
h |
terminal half-life; |
|
DRUGBANK |
Half-life |
5.7 |
h |
5.7(5.2-6.3) |
h |
|
|
The Pharmacological Basis of Therapeutics |
| Toxicity LD50 |
75.0 |
mg/kg |
75.0 |
mg/kg |
PO, oral; Components; Rattus, Rat; |
|
DRUGBANK |
Toxicity LD50 |
75.0 |
mg/kg |
75.0 |
mg/kg |
Rattus, Rat; |
|
T3DB |
| Eliminate Route |
95.0 |
% |
~95 |
% |
Urinary excretion; |
RD, renal impairment, Renal disease，including uremia ↓ ; |
DRUGBANK |
Eliminate Route |
5.0 |
% |
~5 |
% |
Faeces excretion; |
|
DRUGBANK |
Eliminate Route |
30.4 |
% |
30.4 |
% |
Urinary excretion; Unchanged drug; |
RD, renal impairment, Renal disease，including uremia ↓ ; |
DRUGBANK |
Eliminate Route |
20.0 |
% |
20(18-22) |
% |
Urinary excretion; Unchanged drug; |
|
The Pharmacological Basis of Therapeutics |
| Protein Binding |
18.0 |
% |
18 |
% |
plasma proteins; |
|
DRUGBANK |
Protein Binding |
18.0 |
% |
18 |
% |
|
|
The Pharmacological Basis of Therapeutics |
