Drug ID | DDPD00673 |
|
Drug Name | Aprepitant | |
Molecular Weight | 534.4267 | |
Molecular Formula | C23H21F7N4O3 | |
CAS Number | 170729-80-3 | |
SMILES | C[C@@H](O[C@H]1OCCN(CC2=NNC(=O)N2)[C@H]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F | |
External Links | ||
DRUGBANK | DB00673 | |
PubChem Compound | 6918365 | |
Drugs.com | Drugs.com Drug Page |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
---|---|---|---|---|---|
Log P | 4.5 | - | 4.5 | - | DRUGBANK |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
---|---|---|---|---|---|---|
Bioavailability | 62.5 | % | 60-65 | % | DRUGBANK | |
Bioavailability | 62.5 | % | 60-65 | % | PO, oral; | The Pharmacological Basis of Therapeutics |
C Max | 1600.0 | ng/ml | 1.6 | mcg/ml | Oral single dose; | The Pharmacological Basis of Therapeutics |
T Max | 4.0 | h | 4.0 | h | Oral single dose; | The Pharmacological Basis of Therapeutics |
Clearance | 4.6 | L/h | 62-90 | ml/min | Plasma clearance; | DRUGBANK |
Clearance | 0.0654 | L/h/kg | 0.89-1.29 | ml/min/kg | hydrolysis; | The Pharmacological Basis of Therapeutics |
Clearance | 0.0600 | L/h/kg | 1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Volume of Distribution | 70.0 | L | 70.0 | L | DRUGBANK | |
Volume of Distribution | 1.0 | L/kg | 1.0 | L/kg | hydrolysis; | The Pharmacological Basis of Therapeutics |
Volume of Distribution | 0.94 | L/kg | 0.94 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Half-life | 11.0 | h | 9-13 | h | DRUGBANK | |
Half-life | 11.0 | h | 9-13 | h | The Pharmacological Basis of Therapeutics | |
Half-life | 13.0 | h | 13 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Eliminate Route | 0 | % | ~0 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
Protein Binding | 95.0 | % | >95 | % | DRUGBANK | |
Protein Binding | 95.0 | % | >95 | % | The Pharmacological Basis of Therapeutics |
Not Available