Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00671 ...
Drug Name Cefixime
Molecular Weight 453.45
Molecular Formula C16H15N5O7S2
CAS Number 79350-37-1
SMILES [H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC(O)=O)\C1=CSC(N)=N1)C(O)=O
External Links
DRUGBANK DB00671
PubChem Compound 5362065
PDR 299
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.4 - -0.4 - DRUGBANK
Melting Point 220.5 ℃ 218-225 ℃ DRUGBANK
Water Solubility 55.11 mg/L 55.11 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 45.0 % 40-50 % PO, oral; food; food → ; DRUGBANK
Bioavailability 47.0 % 47±15 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 2300.0 ng/ml 1.7-2.9 mcg/ml Capsule, PO, Oral; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 3.5 h 3-4 h Capsule, PO, Oral; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Metabolic 50.0 % 50 % Urinary excretion; DRUGBANK
Clearance 0.0780 L/h/kg 1.3±0.2 ml/min/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.0600 L/h/kg 1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.30 L/kg 0.30±0.03 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.24 L/kg 0.24 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.5 h 3-4 h DRUGBANK
Half-life 11.5 h 11.5 h severe renal function; DRUGBANK
Half-life 3.0 h 3.0±0.4 h RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 3.2 h 3.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 41.0 % 41±7 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 65.0 % 65 % DRUGBANK
Protein Binding 67.0 % 67±1 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 8.0 mg/kg/day 8 mg/kg/day PO, oral Suprax cefixime PDR
Max dose for infants 8.0 mg/kg/day 8 mg/kg/day PO, oral Suprax cefixime PDR
Max dose for children 400.0 mg/day 400 mg/day PO, oral Suprax cefixime PDR
Max dose for children 8.0 mg/kg/day 8 mg/kg/day PO, oral Suprax cefixime PDR
Max dose for adolescents 400.0 mg/day 400 mg/day PO, oral Suprax cefixime PDR
Max dose for adults 400.0 mg/day 400 mg/day PO, oral Suprax cefixime PDR
Max dose for geriatric 400.0 mg/day 400 mg/day PO, oral Suprax cefixime PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1