Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00669 ...
Drug Name Sumatriptan
Molecular Weight 295.4
Molecular Formula C14H21N3O2S
CAS Number 103628-46-2
SMILES CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1
External Links
DRUGBANK DB00669
T3DB T3D2856
PubChem Compound 5358
PDR 199
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.93 - 0.93 - ADLARD,M ET AL. (1995)
Melting Point 169.5 ℃ 169-170 ℃ http://www.chemspider.com/Chemical-Structure.5165.html
Water Solubility 54000.0 mg/L 54 mg/ml Sumatriptan Tablets, USP monograph
pKa 4.9 - 4.9 - Sumatriptan Tablets, USP monograph

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 9.0 ng.h/ml 9(7.5-10.9) ng.h/ml subcutaneous injection, SC; DRUGBANK
AUC 8.7 ng.h/ml 8.7(6.1-12.5) ng.h/ml PO, oral; DRUGBANK
AUC 7.4 ng.h/ml 7.4(5-10.8) ng.h/ml inhalation, IH; DRUGBANK
AUC 14.6 ng.h/ml 14.6(11.3-18.8) ng.h/ml Rectal Administration; DRUGBANK
Bioavailability 100.0 % 100 % subcutaneous injection, SC; DRUGBANK
Bioavailability 14.3 % 14.3(11.4-17.9) % PO, oral; DRUGBANK
Bioavailability 15.8 % 15.8(12.6-19.8) % inhalation, IH; DRUGBANK
Bioavailability 19.2 % 19.2(15.3-24.1) % Rectal Administration; DRUGBANK
Bioavailability 14.0 % 14±5 % PO, oral; The Pharmacological Basis of Therapeutics
Bioavailability 97.0 % 97±16 % subcutaneous injection, SC; The Pharmacological Basis of Therapeutics
C Max 69.5 ng/ml 69.5（62.8-76.9） ng/ml subcutaneous injection, SC; DRUGBANK
C Max 16.5 ng/ml 16.5(13.5-20.1) ng/ml PO, oral; DRUGBANK
C Max 12.9 ng/ml 12.9(10.5-15.9) ng/ml inhalation, IH; DRUGBANK
C Max 22.9 ng/ml 22.9(18.4-28.6) ng/ml Rectal Administration; DRUGBANK
C Max 54.0 ng/ml 54(27-137) ng/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 72.0 ng/ml 72(55-108) ng/ml adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.17 h 0.17(0.08-0.33) h subcutaneous injection, SC; DRUGBANK
T Max 1.5 h 1.5(0.5-2) h PO, oral; DRUGBANK
T Max 1.5 h 1.5(0.25-3) h inhalation, IH; DRUGBANK
T Max 1.0 h 1(0.75-3) h Rectal Administration; DRUGBANK
T Max 1.5 h ~1.5 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.20 h 0.2(0.1-0.3) h adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.0132 L/h 0.22(0.19-0.25) ml/min subcutaneous injection, SC; DRUGBANK
Clearance 0.0105 L/h 0.14-0.21 ml/min PO, oral; Rectal Administration; DRUGBANK
Clearance 0.0129 L/h 0.18-0.25 ml/min IM,intramuscular injection; DRUGBANK
Clearance 72.0 L/h ~1200 ml/min Plasma clearance; DRUGBANK
Clearance 1.3 L/h/kg 22±5.4 ml/min/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Clearance 1.1 L/h/kg 19 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 50.0 L 50±8 L subcutaneous injection, SC; DRUGBANK
Volume of Distribution 2.0 L/kg 2.0±0.34 L/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.7 L/kg 1.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.9 h 1.9 h subcutaneous injection, SC; DRUGBANK
Half-life 1.9 h 1.7-2.0 h subcutaneous injection, SC; 95%CI; DRUGBANK
Half-life 1.7 h 1.7 h PO, oral; DRUGBANK
Half-life 1.7 h 1.4-1.9 h PO, oral; 95%CI; DRUGBANK
Half-life 1.8 h 1.8 h Rectal Administration; DRUGBANK
Half-life 1.9 h 1.6-2.2 h Rectal Administration; 95%CI; DRUGBANK
Half-life 1.8 h 1.8 h DRUGBANK
Half-life 1.9 h 1.7-2.0 h 95%CI; DRUGBANK
Half-life 1.0 h 1.0±0.3 h The Pharmacological Basis of Therapeutics
Half-life 2.0 h ~2 h subcutaneous injection, SC; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 1.7 h 1.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 40.0 % ~40 % Faeces excretion; DRUGBANK
Eliminate Route 24.0 % 24±4 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 22.0 % 22±4 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 17.5 % 14-21 % DRUGBANK
Protein Binding 17.5 % 14-21 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 6.0 mg/dose 6 mg/dose subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for adults 12.0 mg/day 12 mg/day subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for adults 3.0 mg/dose 3 mg/dose subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for adults 12.0 mg/day 12 mg/day subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for adults 100.0 mg/dose 100 mg/dose PO, oral Imitrex Injection sumatriptan succinate PDR
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Imitrex Injection sumatriptan succinate PDR
Max dose for adults 40.0 mg/day 40 mg/day intranasal Imitrex Injection sumatriptan succinate PDR
Max dose for adults 30.0 mg/day 30 mg/day intranasal Imitrex Injection sumatriptan succinate PDR
Max dose for adults 44.0 mg/day 44 mg/day intranasal Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 6.0 mg/dose 6 mg/dose subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 12.0 mg/day 12 mg/day subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 3.0 mg/dose 3 mg/dose subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 12.0 mg/day 12 mg/day subcutaneous injection, SC Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 100.0 mg/dose 100 mg/dose PO, oral Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 200.0 mg/day 200 mg/day PO, oral Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 40.0 mg/day 40 mg/day intranasal Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 30.0 mg/day 30 mg/day intranasal Imitrex Injection sumatriptan succinate PDR
Max dose for geriatric 44.0 mg/day 44 mg/day intranasal Imitrex Injection sumatriptan succinate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1