Basic Information
| Drug ID | DDPD00662 |
|
| Drug Name | Trimethobenzamide | |
| Molecular Weight | 388.4574 | |
| Molecular Formula | C21H28N2O5 | |
| CAS Number | 138-56-7 | |
| SMILES | COC1=CC(=CC(OC)=C1OC)C(=O)NCC1=CC=C(OCCN(C)C)C=C1 | |
| External Links | ||
| DRUGBANK | DB00662 | |
| PubChem Compound | 5577 | |
| PDR | 1494 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.29 | - | 2.29 | - | EL TAYER,N ET AL. (1985) |
| Melting Point | 188.7 | ℃ | 188.7 | ℃ | PhysProp |
| Water Solubility | 40.0 | mg/L | 40 | mg/L | DRUGBANK |
| pKa | 8.78 | - | 8.78 | - | EL TAYAR,N ET AL. (1985) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Half-life | 8.0 | h | 7-9 | h | elimination half-life; | DRUGBANK |
| Toxicity LD50 | 1600.0 | mg/kg | 1600.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 40.0 | % | 30-50 | % | Urinary excretion; Single dose; human, homo sapiens; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 800.0 | mg/day | 800 | mg/day | Capsule, PO, Oral;Rectal Administration; | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for children | 15.0 | mg/kg/day | 15 | mg/kg/day | Capsule, PO, Oral;Rectal Administration; | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for children | 400.0 | mg/day | 400 | mg/day | Capsule, PO, Oral | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for children | 15.0 | mg/kg/day | 15 | mg/kg/day | Rectal Administration | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for adolescents | 800.0 | mg/day | 800 | mg/day | Capsule, PO, Oral;Rectal Administration; | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for adults | 1200.0 | mg/day | 1200 | mg/day | Capsule, PO, Oral | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for adults | 800.0 | mg/day | 800 | mg/day | IM,intramuscular injection;Rectal Administration; | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for elderly | 1200.0 | mg/day | 1200 | mg/day | Capsule, PO, Oral | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
| Max dose for elderly | 800.0 | mg/day | 800 | mg/day | IM,intramuscular injection;Rectal Administration; | Tigan Capsules | trimethobenzamide hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1