Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00660 ...
Drug Name Metaxalone
Molecular Weight 221.2524
Molecular Formula C12H15NO3
CAS Number 1665-48-1
SMILES CC1=CC(OCC2CNC(=O)O2)=CC(C)=C1
External Links
DRUGBANK DB00660
PubChem Compound 15459
PDR 2343
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.3 - 2.3 - DRUGBANK
Melting Point 122.0 ℃ 122 ℃ PhysProp

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 1700.0 ng/ml 1.7 mcg/ml Oral single dose; fasting; The Pharmacological Basis of Therapeutics
C Max 4900.0 ng/ml 4.9 mcg/ml Oral single dose; food; The Pharmacological Basis of Therapeutics
T Max 3.0 h 3.0±1.2 h Oral single dose; fasting; The Pharmacological Basis of Therapeutics
T Max 4.9 h 4.9±2.3 h Oral single dose; food; The Pharmacological Basis of Therapeutics
Clearance 68.0 L/h 68±50 L/h Tablet, PO, oral; fasting; DRUGBANK
Clearance 66.0 L/h 66±51 L/h Tablet, PO, oral; fasting; DRUGBANK
Clearance 0.84 L/h/kg 14±7 ml/min/kg apparent clearance; Oral single dose; The Pharmacological Basis of Therapeutics
Volume of Distribution 800.0 L 800.0 L DRUGBANK
Half-life 9.2 h 9.2±4.8 h DRUGBANK
Half-life 9.2 h 9.2±4.8 h fasting; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 2.4 h 2.4±1.2 h food; PO, oral; The Pharmacological Basis of Therapeutics
Toxicity LD50 775.0 mg/kg 775.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1690.0 mg/kg 1690.0 mg/kg PO, oral; mouse; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 3200.0 mg/day 3200 mg/day PO, oral Skelaxin metaxalone PDR
Max dose for adults 3200.0 mg/day 3200 mg/day PO, oral Skelaxin metaxalone PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1