Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00656 ...
Drug Name Trazodone
Molecular Weight 371.864
Molecular Formula C19H22ClN5O
CAS Number 19794-93-5
SMILES ClC1=CC=CC(=C1)N1CCN(CCCN2N=C3C=CC=CN3C2=O)CC1
External Links
DRUGBANK DB00656
T3DB T3D2852
PubChem Compound 5533
PDR 3033
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.68 - 2.68 - http://www.t3db.ca/toxins/T3D2852
Boiling Point 528.5 ℃ 528.5 ℃ https://www.lookchem.com/Trazodone/
Melting Point 232.5 ℃ 231-234 ℃ https://pdf.hres.ca/dpd_pm/00007839.PDF
pKa 6.74 - 6.74 - https://patents.google.com/patent/EP1931346B1
Log S -3.1 - -3.1 - http://www.t3db.ca/toxins/T3D2852

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 18193.0 ng.h/ml 18193.0 ng.h/ml PO, oral; DRUGBANK
Bioavailability 77.0 % 63-91 % PO, oral; DRUGBANK
Bioavailability 81.0 % 81±6 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1470.0 ng/ml 1.47±0.16 mcg/ml PO, oral; food; food ↓ ; DRUGBANK
C Max 1880.0 ng/ml 1.88±0.42 mcg/ml PO, oral; fasting; DRUGBANK
C Max 1500.0 ng/ml 1.5±0.2 mcg/ml Capsule, PO, Oral; food; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 8.0 h 8 h Oral single dose; DRUGBANK
T Max 2.0 h 2.0±1.5 h Capsule, PO, Oral; food; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 5.1 L/h 5.1 L/h Total clearance; Elderly; fasting; DRUGBANK
Clearance 5.3 L/h 5.3±0.9 L/h Total clearance; normal,healthy; patients; DRUGBANK
Clearance 0.13 L/h/kg 2.1±0.1 ml/min/kg hydrolysis; Elderly ↓ ;Obesity ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.0840 L/h/kg 1.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.84 L/kg 0.84±0.16 L/kg Single dose; DRUGBANK
Volume of Distribution 0.66 L/kg 0.47-0.84 L/kg DRUGBANK
Volume of Distribution 1.0 L/kg 1.0±0.1 L/kg Apparent volume of distribution; hydrolysis; Elderly ↑ ;Obesity ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.52 L/kg 0.52 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 6.0 h 6 h elimination half-life; young; DRUGBANK
Half-life 13.6 h 13.6 h elimination half-life; Elderly; DRUGBANK
Half-life 7.3 h 7.3±0.8 h elimination half-life; normal,healthy; Single dose; DRUGBANK
Half-life 4.5 h 3-6 h distribution half-life; DRUGBANK
Half-life 7.0 h 5-9 h elimination half-life; DRUGBANK
Half-life 5.9 h 5.9±0.4 h Obesity ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 7.3 h 7.3 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 690.0 mg/kg 690.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 96.0 mg/kg 96.0 mg/kg intravenous injection, IV; mouse; T3DB
Eliminate Route 65.0 % ~60-70 % Urinary excretion; DRUGBANK
Eliminate Route 19.0 % 9-29 % Faeces excretion; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 92.0 % 89-95 % plasma proteins; DRUGBANK
Protein Binding 93.0 % 93 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 6.0 mg/kg/day 6 mg/kg/day PO, oral Trazodone Hydrochloride trazodone hydrochloride PDR
Max dose for adolescents 150.0 mg/day 150 mg/day PO, oral Trazodone Hydrochloride trazodone hydrochloride PDR
Max dose for adults 400.0 mg/day 400 mg/day Tablet,PO，oral Trazodone Hydrochloride trazodone hydrochloride PDR
Max dose for adults 600.0 mg/day 600 mg/day Tablet,PO，oral Trazodone Hydrochloride trazodone hydrochloride PDR
Max dose for adults 375.0 mg/day 375 mg/day Tablet,PO，oral Trazodone Hydrochloride trazodone hydrochloride PDR
Max dose for geriatric 400.0 mg/day 400 mg/day Tablet,PO，oral Trazodone Hydrochloride trazodone hydrochloride PDR
Max dose for geriatric 600.0 mg/day 600 mg/day Tablet,PO，oral Trazodone Hydrochloride trazodone hydrochloride PDR
Max dose for geriatric 375.0 mg/day 375 mg/day Tablet,PO，oral Trazodone Hydrochloride trazodone hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1