Basic Information
| Drug ID | DDPD00654 |
|
| Drug Name | Latanoprost | |
| Molecular Weight | 432.5928 | |
| Molecular Formula | C26H40O5 | |
| CAS Number | 130209-82-4 | |
| SMILES | CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00654 | |
| PubChem Compound | 5311221 | |
| PDR | 2298 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.18 | - | 2.18 | - | https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL448/ |
| Boiling Point | 583.8 | ℃ | 583.8 | ℃ | https://www.lookchem.com/Latanoprost/ |
| pKa | 7.93 | - | 7.93 | - | https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL448/ |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 0.0530 | ng/ml | 53.0 | pg/ml | ophthalmic administration; | DRUGBANK |
| T Max | 0.0833 | h | 5 | min | ophthalmic administration; | DRUGBANK |
| Clearance | 0.42 | L/h/kg | 7.0 | ml/min/kg | Total clearance; | DRUGBANK | Clearance | 0.40 | L/h/kg | 6.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.16 | L/kg | 0.16±0.02 | L/kg | DRUGBANK | |
| Half-life | 0.28 | h | ~17 | min | elimination half-life; | DRUGBANK | Half-life | 2.5 | h | ~2-3 | h | elimination half-life; | DRUGBANK | Half-life | 0.28 | h | 0.28 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 50.0 | mg/kg | >50 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 88.0 | % | ~88 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 15.0 | % | ~15 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 90.0 | % | ~90 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Xalatan | latanoprost | PDR |
| Max dose for geriatric | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Xalatan | latanoprost | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1