Basic Information
| Drug ID | DDPD00650 |
|
| Drug Name | Leucovorin | |
| Molecular Weight | 473.446 | |
| Molecular Formula | C20H23N7O7 | |
| CAS Number | 58-05-9 | |
| SMILES | [H]C(=O)N1C(CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 | |
| External Links | ||
| DRUGBANK | DB00650 | |
| T3DB | T3D2849 | |
| PubChem Compound | 6006 | |
| PDR | 1570 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -3.2 | - | -3.2 | - | DRUGBANK |
| Melting Point | 245.0 | ℃ | 245 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 97.0 | % | 97 | % | DRUGBANK | Bioavailability | 75.0 | % | 75 | % | DRUGBANK | Bioavailability | 37.0 | % | 37 | % | DRUGBANK |
| Half-life | 6.2 | h | 6.2 | h | DRUGBANK | |
| Toxicity LD50 | 8000.0 | mg/kg | >8000 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 8000.0 | mg/kg | >8000 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Protein Binding | 15.0 | % | ~15 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1