Basic Information
| Drug ID | DDPD00648 |
|
| Drug Name | Mitotane | |
| Molecular Weight | 320.041 | |
| Molecular Formula | C14H10Cl4 | |
| CAS Number | 53-19-0 | |
| SMILES | ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl | |
| External Links | ||
| DRUGBANK | DB00648 | |
| T3DB | T3D0151 | |
| PubChem Compound | 4211 | |
| PDR | 907 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.0 | - | 6.0 | - | DRUGBANK |
| Melting Point | 77.0 | ℃ | 77 | ℃ | PhysProp |
| Water Solubility | 0.1 | mg/L | 0.1 | mg/L | BIGGAR,JW & RIGGS,RI 1974) |
| Log S | -6.51 | - | -6.51 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 40.0 | % | 40 | % | PO, oral; | DRUGBANK |
| Half-life | 2124.0 | h | 18-159 | day | DRUGBANK | |
| Toxicity LD50 | 113.0 | mg/kg | 113.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Toxicity Lethal Dose | 5000.0 | mg/kg | 5.0 | g/kg | adults; human, homo sapiens; | T3DB |
| Eliminate Route | 9.0 | % | 1-17 | % | Bile excretion; | DRUGBANK |
| Protein Binding | 6.0 | % | 6 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1