Basic Information
| Drug ID | DDPD00642 |
|
| Drug Name | Pemetrexed | |
| Molecular Weight | 427.4106 | |
| Molecular Formula | C20H21N5O6 | |
| CAS Number | 137281-23-3 | |
| SMILES | NC1=NC(=O)C2=C(NC=C2CCC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N1 | |
| External Links | ||
| DRUGBANK | DB00642 | |
| PubChem Compound | 446556 | |
| PDR | 2260 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.5 | - | -1.5 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 5.5 | L/h | 91.8 | ml/min | intravenous infusion, IV in drop; tumor; patients; normal,healthy; | DRUGBANK | Clearance | 0.0780 | L/h/kg | 1.3 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 16.1 | L | 16.1 | L | DRUGBANK | Volume of Distribution | 0.15 | L/kg | 0.15 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.5 | h | 3.5 | h | DRUGBANK | Half-life | 1.9 | h | 1.85 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 80.0 | % | 70-90 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 81.0 | % | 81 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 500.0 | mg/m2 | 500 | mg/m2 | intravenous infusion, iv in drop | q3w | Alimta | pemetrexed disodium | PDR |
| Max dose for geriatric | 500.0 | mg/m2 | 500 | mg/m2 | intravenous infusion, iv in drop | q3w | Alimta | pemetrexed disodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1