Basic Information
| Drug ID | DDPD00637 |
|
| Drug Name | Astemizole | |
| Molecular Weight | 458.5703 | |
| Molecular Formula | C28H31FN4O | |
| CAS Number | 68844-77-9 | |
| SMILES | COC1=CC=C(CCN2CCC(CC2)NC2=NC3=CC=CC=C3N2CC2=CC=C(F)C=C2)C=C1 | |
| External Links | ||
| DRUGBANK | DB00637 | |
| T3DB | T3D2844 | |
| PubChem Compound | 2247 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.8 | - | 5.8 | - | DRUGBANK |
| Melting Point | 149.1 | ℃ | 149.1 | ℃ | PhysProp |
| Water Solubility | 432.0 | mg/L | 432 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 100.0 | % | ~100 | % | Liver metabolism; Faeces excretion; | DRUGBANK |
| Half-life | 24.0 | h | 1 | day | DRUGBANK | |
| Toxicity LD50 | 2052.0 | mg/kg | 2052.0 | mg/kg | mouse; | DRUGBANK | Toxicity LD50 | 2052.0 | mg/kg | 2052.0 | mg/kg | mouse; | T3DB |
| Protein Binding | 96.7 | % | 96.7 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1