Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00635 ...
Drug Name Prednisone
Molecular Weight 358.4281
Molecular Formula C21H26O5
CAS Number 53-03-2
SMILES [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
External Links
DRUGBANK DB00635
T3DB T3D4710
PubChem Compound 5865
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.46 - 1.46 - MSDS
Melting Point 232.5 ℃ 230-235 ℃ MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 572.0 mg.min/1.73m2 572.0 mg.min/1.73m2 PO, oral; DRUGBANK
AUC 1034.0 mg.min/1.73m2 1034.0 mg.min/1.73m2 PO, oral; DRUGBANK
AUC 2271.0 mg.min/1.73m2 2271.0 mg.min/1.73m2 DRUGBANK
Bioavailability 80.0 % 80±11 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 71.5 ng/ml 62-81 ng/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 218.5 ng/ml 198-239 ng/ml Oral single dose; Active metabolite; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2 h PO, oral; DRUGBANK
T Max 6.3 h 6-6.5 h PO, oral; extended release formulation; DRUGBANK
T Max 2.6 h 2.1-3.1 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.9 h 1.2-2.6 h Oral single dose; Active metabolite; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.0660 L/h/kg 0.066±0.12 L/h/kg Average clearance; intravenous infusion, IV in drop; DRUGBANK
Clearance 0.15 L/h/kg 0.15 L/h/kg Average clearance; intravenous infusion, IV in drop; DRUGBANK
Clearance 0.22 L/h/kg 3.6±0.8 ml/min/kg Hepatitis, Hep → ; The Pharmacological Basis of Therapeutics
Clearance 0.15 L/h/kg 2.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 29.3 L 29.3 L DRUGBANK
Volume of Distribution 44.2 L 44.2 L DRUGBANK
Volume of Distribution 0.97 L/kg 0.97±0.11 L/kg Hepatitis, Hep → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.57 L/kg 0.57 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h 2 h immediate release formulation; extended release formulation; DRUGBANK
Half-life 2.0 h 2 h immediate release formulation; extended release formulation; DRUGBANK
Half-life 3.6 h 3.6±0.4 h Hepatitis, Hep → ;Somking → ; The Pharmacological Basis of Therapeutics
Half-life 2.9 h 2.9 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 3.0 % 3±2 % Urinary excretion; Unchanged drug; hyperthyroid, HTh → ; The Pharmacological Basis of Therapeutics
Protein Binding 50.0 % <50 % DRUGBANK
Protein Binding 75.0 % 75±2 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1