Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00633 ...
Drug Name Dexmedetomidine
Molecular Weight 200.2795
Molecular Formula C13H16N2
CAS Number 113775-47-6
SMILES C[C@H](C1=CNC=N1)C1=C(C)C(C)=CC=C1
External Links
DRUGBANK DB00633
PubChem Compound 5311068
PDR 1271

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.8 - 2.8 - DRUGBANK
pKa 7.1 - 7.1 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 39.0 L/h 39.0 L/h intravenous infusion, IV in drop; normal,healthy; rheumatoid arthritis; DRUGBANK
Clearance 0.66 L/h/kg 11 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 118.0 L 118.0 L DRUGBANK
Volume of Distribution 1.6 L/kg 1.6 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h 2 h DRUGBANK
Half-life 2.2 h 2.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 95.0 % 95 % Urinary excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 4.0 % 4 % Faeces excretion; intravenous injection, IV; DRUGBANK
Protein Binding 94.0 % 94 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 0.0005 mg/kg 0.5 mcg/kg intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for neonates 0.048 mg/kg/day 2 mcg/kg/hour intravenous infusion, iv in drop Precedex dexmedetomidine hydrochloride PDR
Max dose for neonates 0.0005 mg/kg 0.5 mcg/kg intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for neonates 0.048 mg/kg/day 2 mcg/kg/hour intravenous infusion, iv in drop Precedex dexmedetomidine hydrochloride PDR
Max dose for infants 0.001 mg/kg 1 mcg/kg intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for infants 0.06 mg/kg/day 2.5 mcg/kg/h intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for infants 0.0204 mg/kg/day 0.85 mcg/kg/h intravenous infusion, iv in drop Precedex dexmedetomidine hydrochloride PDR
Max dose for children 0.001 mg/kg 1 mcg/kg intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for children 0.06 mg/kg/day 2.5 mcg/kg/hour intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for children 0.0204 mg/kg/day 0.85 mcg/kg/hour intravenous infusion, iv in drop Precedex dexmedetomidine hydrochloride PDR
Max dose for adolescents 0.001 mg/day 1 mcg/kg intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for adolescents 0.0025 mg/kg/day 2.5 mcg/kg/hour intravenous injection, IV Precedex dexmedetomidine hydrochloride PDR
Max dose for adolescents 0.00085 mg/kg/day 0.85 mcg/kg/hour intravenous infusion, iv in drop Precedex dexmedetomidine hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1