Basic Information
| Drug ID | DDPD00631 |
|
| Drug Name | Clofarabine | |
| Molecular Weight | 303.677 | |
| Molecular Formula | C10H11ClFN5O3 | |
| CAS Number | 123318-82-1 | |
| SMILES | [H][C@]1(F)[C@H](O)[C@@H](CO)O[C@H]1N1C=NC2=C(N)N=C(Cl)N=C12 | |
| External Links | ||
| DRUGBANK | DB00631 | |
| PubChem Compound | 119182 | |
| PDR | 2470 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.0 | - | 0.0 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 28.8 | L/h/m2 | 28.8 | L/h/m2 | Children; Adolescents; Acute leukaemia; | DRUGBANK | Clearance | 0.46 | L/h/kg | 7.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 172.0 | L/m2 | 172.0 | L/m2 | DRUGBANK | Volume of Distribution | 1.8 | L/kg | 1.75 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.2 | h | 5.2 | h | terminal half-life; | DRUGBANK | Half-life | 4.0 | h | 4 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 54.5 | % | 49-60 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 47.0 | % | 47 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 52.0 | mg/m2/day | 52 | mg/m2/day | intravenous injection, IV | Clolar | clofarabine | PDR |
| Max dose for adolescents | 52.0 | mg/m2/day | 52 | mg/m2/day | intravenous injection, IV | Clolar | clofarabine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1