Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00628 ...
Drug Name Clorazepic acid
Molecular Weight 314.723
Molecular Formula C16H11ClN2O3
CAS Number 23887-31-2
SMILES OC(=O)C1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2
External Links
DRUGBANK DB00628
T3DB T3D2842
PubChem Compound 2809
PDR 1708
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.0 - 3.0 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 91.0 % 91 % PO, oral; DRUGBANK
Bioavailability 91.0 % 91±6 % PO, oral; Drug form; The Pharmacological Basis of Therapeutics
C Max 275.0 ng/ml 275±27 ng/ml IM,intramuscular injection; Drug form; The Pharmacological Basis of Therapeutics
T Max 0.72 h 0.72±0.01 h IM,intramuscular injection; Drug form; The Pharmacological Basis of Therapeutics
Clearance 0.0102 L/h/kg 0.17±0.02 ml/min/kg Elderly → ;Hepatitis, Hep ↓ ;Obesity ↓ ;Somking ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.2 L/kg 1.24±0.09 L/kg Elderly → ;Obesity ↑ ;Hepatitis, Hep → ; The Pharmacological Basis of Therapeutics
Half-life 48.0 h ~2 day elimination half-life; DRUGBANK
Half-life 45.0 h ~40-50 h DRUGBANK
Half-life 93.0 h 93±11 h intravenous injection, IV; Preg, pregnant ↑ ;Obesity ↑ ;Hepatic cirrhosis, cirr ↓ ;Hepatitis, Hep ↓ ;Age ↑ ;Somking ↓ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 1320.0 mg/kg 1320.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1600.0 mg/kg >1600 mg/kg PO, oral; monkey; DRUGBANK
Toxicity LD50 1320.0 mg/kg 1320.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 1600.0 mg/kg >1600 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 97.5 % 97-98 % plasma proteins; DRUGBANK
Protein Binding 97.5 % 97.5 % Elderly → ;RD, renal impairment, Renal disease，including uremia ↓ ;Obesity → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 60.0 mg/day 60 mg/day PO, oral Tranxene clorazepate dipotassium PDR
Max dose for adolescents 60.0 mg/kg 60 mg/kg PO, oral Tranxene clorazepate dipotassium PDR
Max dose for adolescents 90.0 mg/kg 90 mg/kg PO, oral Tranxene clorazepate dipotassium PDR
Max dose for adults 60.0 mg/kg 60 mg/kg PO, oral Tranxene clorazepate dipotassium PDR
Max dose for adults 90.0 mg/kg 90 mg/kg PO, oral Tranxene clorazepate dipotassium PDR
Max dose for geriatric 60.0 mg/kg 60 mg/kg PO, oral Tranxene clorazepate dipotassium PDR
Max dose for geriatric 90.0 mg/kg 90 mg/kg PO, oral Tranxene clorazepate dipotassium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1