Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00625 ...
Drug Name Efavirenz
Molecular Weight 315.675
Molecular Formula C14H9ClF3NO2
CAS Number 154598-52-4
SMILES FC(F)(F)[C@]1(OC(=O)NC2=C1C=C(Cl)C=C2)C#CC1CC1
External Links
DRUGBANK DB00625
PubChem Compound 64139
PDR 116
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.6 - 4.6 - DRUGBANK
Melting Point 140.0 ℃ 139-141 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 4000.0 ng/ml 4.0±1.7 mcg/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 4.1 h 4.1±1.7 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 0.19 L/h/kg 3.1±1.2 ml/min/kg apparent clearance; PO, oral; Children → ; The Pharmacological Basis of Therapeutics
Half-life 47.5 h 40-55 h DRUGBANK
Half-life 64.0 h 52-76 h Oral single dose; The Pharmacological Basis of Therapeutics
Half-life 47.5 h 40-55 h Oral multiple dose; The Pharmacological Basis of Therapeutics
Eliminate Route 1.0 % <1 % Urinary excretion; AIDS,HIV; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.6 % 99.5-99.75 % DRUGBANK
Protein Binding 99.6 % 99.5-99.75 % AIDS,HIV; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 200.0 mg/day 200 mg/day PO, oral Sustiva efavirenz PDR
Max dose for infants 150.0 mg/day 150 mg/day PO, oral Sustiva efavirenz PDR
Max dose for infants 100.0 mg/day 100 mg/day PO, oral Sustiva efavirenz PDR
Max dose for children 600.0 mg/day 600 mg/day PO, oral Sustiva efavirenz PDR
Max dose for children 400.0 mg/day 400 mg/day PO, oral Sustiva efavirenz PDR
Max dose for children 350.0 mg/day 350 mg/day PO, oral Sustiva efavirenz PDR
Max dose for children 300.0 mg/day 300 mg/day PO, oral Sustiva efavirenz PDR
Max dose for children 250.0 mg/day 250 mg/day PO, oral Sustiva efavirenz PDR
Max dose for children 200.0 mg/day 200 mg/day PO, oral Sustiva efavirenz PDR
Max dose for children 150.0 mg/day 150 mg/day PO, oral Sustiva efavirenz PDR
Max dose for adolescents 600.0 mg/day 600 mg/day PO, oral Sustiva efavirenz PDR
Max dose for adolescents 400.0 mg/day 400 mg/day PO, oral Sustiva efavirenz PDR
Max dose for adolescents 350.0 mg/day 350 mg/day PO, oral Sustiva efavirenz PDR
Max dose for adults 600.0 mg/day 600 mg/day PO, oral Sustiva efavirenz PDR
Max dose for geriatric 600.0 mg/day 600 mg/day PO, oral Sustiva efavirenz PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1