Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -4.34 | - | -4.34 | - | ADME Research, USCD |
| Log P | 3.32 | - | 3.32 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 155.0 | ℃ | 155 | ℃ | PhysProp |
| Water Solubility | 23.4 | mg/L | 23.4 | mg/L | YALKOWSKY,SH & HE,Y 2003) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 104.3 | ng.h/ml | 10425±5521 | ng.h/dl | DRUGBANK | |
| Bioavailability | 10.0 | % | ~10 | % | DRUGBANK | |
| C Max | 57300.0 | ng/ml | 573±284 | ng/dl | DRUGBANK | |
| Clearance | 33.8 | L/h | 812±64 | L/day | Average clearance; adults; Male, men; | DRUGBANK | Clearance | 1.5 | L/h/kg | 24.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 80.4 | L | 80.36±24.51 | L | Elderly; Male, men; | DRUGBANK | Volume of Distribution | 0.35 | L/kg | 0.35 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.92 | h | 10-100 | min | DRUGBANK | Half-life | 0.17 | h | 0.17 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 90.0 | % | 90 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 6.0 | % | 6 | % | Faeces excretion; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1