Basic Information
| Drug ID | DDPD00623 |
|
| Drug Name | Fluphenazine | |
| Molecular Weight | 437.522 | |
| Molecular Formula | C22H26F3N3OS | |
| CAS Number | 69-23-8 | |
| SMILES | OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 | |
| External Links | ||
| DRUGBANK | DB00623 | |
| T3DB | T3D2840 | |
| PubChem Compound | 3372 | |
| PDR | 1262 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.36 | - | 4.36 | - | HANSCH,C ET AL. (1995) |
| Boiling Point | 271.0 | ℃ | 268-274 | ℃ | PhysProp |
| Melting Point | 225.0 | ℃ | 224-226 | ℃ | U.S. Patent 3,058,979 |
| Water Solubility | 31.1 | mg/L | 31.1 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 7.9 | - | 7.9 | - | EL TAYAR,N ET AL. (1985) |
| Log S | -4.15 | - | -4.15 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 2.7 | % | 2.7(1.7-4.5) | % | PO, oral; immediate release formulation; | The Pharmacological Basis of Therapeutics | Bioavailability | 3.4 | % | 3.4(2.5-5.0) | % | IM,intramuscular injection; subcutaneous injection, SC; | The Pharmacological Basis of Therapeutics |
| C Max | 2.3 | ng/ml | 2.3±2.1 | ng/ml | PO, oral; immediate release formulation; | The Pharmacological Basis of Therapeutics | C Max | 1.3 | ng/ml | 1.3 | ng/ml | IM,intramuscular injection; Drug form; | The Pharmacological Basis of Therapeutics | C Max | 1.1 | ng/ml | 1.1 | ng/ml | IM,intramuscular injection; Drug form; | The Pharmacological Basis of Therapeutics |
| T Max | 2.8 | h | 2.8±2.1 | h | PO, oral; immediate release formulation; | The Pharmacological Basis of Therapeutics | T Max | 36.0 | h | 24-48 | h | IM,intramuscular injection; Drug form; | The Pharmacological Basis of Therapeutics | T Max | 60.0 | h | 48-72 | h | IM,intramuscular injection; Drug form; | The Pharmacological Basis of Therapeutics |
| Clearance | 0.60 | L/h/kg | 10±7 | ml/min/kg | normal,healthy; adults; | The Pharmacological Basis of Therapeutics | Clearance | 0.58 | L/h/kg | 9.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 11.0 | L/kg | 11±10 | L/kg | normal,healthy; adults; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 2.9 | L/kg | 2.9 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 12.0 | h | 12±4 | h | The Pharmacological Basis of Therapeutics | Half-life | 14.4 | h | 14.4±7.8 | h | PO, oral; immediate release formulation; | The Pharmacological Basis of Therapeutics | Half-life | 20.3 | h | 20.3±7.9 | h | PO, oral; extended release formulation; | The Pharmacological Basis of Therapeutics | Half-life | 12.3 | h | 12.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 0 | % | ~0 | % | Urinary excretion; adults; normal,healthy; human, homo sapiens; Unchanged drug; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 20.0 | mg/day | 20 | mg/day | PO, oral | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
| Max dose for adults | 100.0 | mg/dose | 100 | mg/dose | subcutaneous injection, SC;IM,intramuscular injection; | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | IM,intramuscular injection | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
| Max dose for geriatric | 20.0 | mg/day | 20 | mg/day | PO, oral | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
| Max dose for geriatric | 100.0 | mg/dose | 100 | mg/dose | subcutaneous injection, SC;IM,intramuscular injection; | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
| Max dose for geriatric | 10.0 | mg/day | 10 | mg/day | IM,intramuscular injection | Fluphenazine Decanoate | fluphenazine decanoate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1