Basic Information
| Drug ID | DDPD00622 |
|
| Drug Name | Nicardipine | |
| Molecular Weight | 479.525 | |
| Molecular Formula | C26H29N3O6 | |
| CAS Number | 55985-32-5 | |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00622 | |
| PubChem Compound | 4474 | |
| PDR | 1798 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.82 | - | 3.82 | - | SANGSTER (1993) |
| Melting Point | 137.0 | ℃ | 136-138 | ℃ | PhysProp |
| Water Solubility | 2.2 | mg/L | 2.2 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100 | % | DRUGBANK | |
| Bioavailability | 35.0 | % | 35 | % | PO, oral; | DRUGBANK |
| Clearance | 0.40 | L/h/kg | 0.4 | L/h/kg | intravenous infusion, IV in drop; | DRUGBANK | Clearance | 0.66 | L/h/kg | 11 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 8.3 | L/kg | 8.3 | L/kg | DRUGBANK | Volume of Distribution | 1.0 | L/kg | 1 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.6 | h | 8.6 | h | DRUGBANK | Half-life | 4.1 | h | 4.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 184.0 | mg/kg | 184.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 322.0 | mg/kg | 322.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Protein Binding | 95.0 | % | >95 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 4.32 | mg/kg/day | 3 | mcg/kg/minute | intravenous injection, IV | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for neonates | 8.64 | mg/kg/day | 6 | mcg/kg/minute | intravenous injection, IV | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for infants | 14.4 | mg/kg/day | 10 | mcg/kg/min | intravenous injection, IV | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for children | 14.4 | mg/kg/day | 10 | mcg/kg/minute | intravenous injection, IV | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for adolescents | 14.4 | mg/kg/day | 10 | mcg/kg/minute | intravenous injection, IV | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for adolescents | 90.0 | mg/day | 90 | mg/day | Tablet,PO，oral | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for adults | 120.0 | mg/day | 120 | mg/day | Tablet,PO，oral | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for adults | 360.0 | mg/day | 15 | mg/h | intravenous injection, IV; up to 15 minutes | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for geriatric | 120.0 | mg/day | 120 | mg/day | Tablet,PO，oral | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
| Max dose for geriatric | 360.0 | mg/day | 15 | mg/hour | intravenous injection, IV; up to 15 minutes | Nicardipine Hydrochloride Capsules | nicardipine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1