Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00620 ...
Drug Name Triamcinolone
Molecular Weight 394.4339
Molecular Formula C21H27FO6
CAS Number 124-94-7
SMILES [H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
External Links
DRUGBANK DB00620
T3DB T3D4756
PubChem Compound 31307
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 270.0 ℃ 270 ℃ Chemspider

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 36.0 ng.h/ml 36.0±6.2 ng.h/ml PO, oral; DRUGBANK
AUC 57.7 ng.h/ml 57.7 ng.h/ml intravenous injection, IV; DRUGBANK
AUC 5.1 ng.h/ml 5.12 ng.h/ml inhalation, IH; DRUGBANK
AUC 32.7 ng.h/ml 32.7±9.9 ng.h/ml PO, oral; DRUGBANK
Bioavailability 25.0 % 25 % inhalation, IH; DRUGBANK
C Max 5.2 ng/ml 5.23±0.84 ng/ml PO, oral; DRUGBANK
C Max 0.92 ng/ml 0.92 ng/ml inhalation, IH; DRUGBANK
C Max 5.3 ng/ml 5.33±1.55 ng/ml PO, oral; DRUGBANK
T Max 2.2 h 2.24±0.78 h PO, oral; DRUGBANK
T Max 1.7 h 1.74 h inhalation, IH; DRUGBANK
T Max 1.9 h 1.86±0.47 h PO, oral; DRUGBANK
Clearance 28.6 L/h 28.6±5.6 L/h DRUGBANK
Clearance 0.57 L/h 0.57 L/h Average clearance; DRUGBANK
Clearance 34.4 L/h 34.4±10.6 L/h Average clearance; DRUGBANK
Volume of Distribution 115.2 L 115.2±10 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 2.0 L/kg 1.96 L/kg Apparent volume of distribution; DRUGBANK
Volume of Distribution 119.7 L 119.7±33.14 L Apparent volume of distribution; DRUGBANK
Half-life 2.7 h 2.7 h DRUGBANK
Half-life 2.4 h 2.4 h elimination half-life; inhalation, IH; DRUGBANK
Half-life 2.8 h 2.8 h DRUGBANK
Toxicity LD50 13.1 mg/kg 13100.0 ug/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity LD50 132.0 mg/kg 132.0 mg/kg subcutaneous injection, SC; mouse; DRUGBANK
Toxicity LD50 1451.0 mg/kg 1451.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 2168.0 mg/kg 2168.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 105.0 mg/kg 105.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Toxicity LD50 500.0 mg/kg >500 mg/kg Rattus, Rat; T3DB
Eliminate Route 50.0 % ~50 % Urinary excretion; DRUGBANK
Eliminate Route 20.0 % ~20 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 98.0 % ~98 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1