Basic Information
| Drug ID | DDPD00615 |
|
| Drug Name | Rifabutin | |
| Molecular Weight | 847.0047 | |
| Molecular Formula | C46H62N4O11 | |
| CAS Number | 72559-06-9 | |
| SMILES | CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(=O)C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC3(CCN(CC3)CC(C)C)N=C21 | |
| External Links | ||
| DRUGBANK | DB00615 | |
| T3DB | T3D2838 | |
| PubChem Compound | 6323490 | |
| PDR | 1879 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.1 | - | 4.1 | - | DRUGBANK |
| Water Solubility | 190.0 | mg/L | 0.19 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.69 | L/h/kg | 0.69±0.32 | L/h/kg | DRUGBANK | Clearance | 0.14 | L/h/kg | 2.4 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 9.3 | L/kg | 9.3 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 45.0 | h | 45±17 | h | DRUGBANK | Half-life | 37.0 | h | 37 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 4800.0 | mg/kg | 4.8 | g/kg | male mouse; | DRUGBANK | Toxicity LD50 | 4800.0 | mg/kg | 4.8 | g/kg | male mouse; | T3DB |
| Eliminate Route | 53.0 | % | 53 | % | Urinary excretion; PO, oral; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 30.0 | % | ~30 | % | Faeces excretion; PO, oral; adults; normal,healthy; human, homo sapiens; | DRUGBANK |
| Protein Binding | 85.0 | % | 85 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 20.0 | mg/kg/day | 20 | mg/kg/day | PO, oral | Mycobutin | rifabutin | PDR |
| Max dose for children | 20.0 | mg/kg/day | 20 | mg/kg/day | PO, oral | Mycobutin | rifabutin | PDR |
| Max dose for children | 300.0 | mg/day | 300 | mg/day | PO, oral | Mycobutin | rifabutin | PDR |
| Max dose for adolescents | 300.0 | mg/day | 300 | mg/day | PO, oral | Mycobutin | rifabutin | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Mycobutin | rifabutin | PDR |
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | PO, oral | Mycobutin | rifabutin | PDR |
| Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | PO, oral | Mycobutin | rifabutin | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | PO, oral | Mycobutin | rifabutin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1