Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00612 ...
Drug Name Bisoprolol
Molecular Weight 325.443
Molecular Formula C18H31NO4
CAS Number 66722-44-9
SMILES CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1
External Links
DRUGBANK DB00612
PubChem Compound 2405
PDR 632
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.2 - 2.2 - http://www.hmdb.ca/metabolites/HMDB0014750
Boiling Point 445.0 ℃ 445.0±45.0 ℃ http://www.chemspider.com/Chemical-Structure.2312.html
Melting Point 101.5 ℃ 100-103 ℃ https://www.sandoz.ca/sites/www.sandoz.ca/files/Bisoprolol_TAB_Monograph.pdf
pKa 9.5 - 9.5 - https://www.sandoz.ca/sites/www.sandoz.ca/files/Bisoprolol_TAB_Monograph.pdf
Log S -3.7 - -3.7 - http://www.hmdb.ca/metabolites/HMDB0014750

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 642870000000.0 ng.h/ml 642.87 g.h/ml PO, oral; DRUGBANK
Bioavailability 90.0 % 90 % PO, oral; DRUGBANK
C Max 64.0 ng/ml 64±21 ng/ml Oral multiple dose; DRUGBANK
Css 52.0 ng/ml 52.0 mcg/L Oral multiple dose; DRUGBANK
T Max 3.0 h 2-4 h PO, oral; DRUGBANK
Tss 120.0 h 5.0 day PO, oral; DRUGBANK
Metabolic 50.0 % 50 % Inactive metabolite; DRUGBANK
Clearance 14.2 L/h 14.2 L/h Total clearance; normal,healthy; patients; DRUGBANK
Clearance 7.8 L/h 7.8 L/h Total clearance; RD, renal impairment, Renal disease，including uremia; patients; hepatopathy，LD ↓ ; DRUGBANK
Clearance 0.22 L/h/kg 3.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 3.5 L/kg 3.5 L/kg DRUGBANK
Volume of Distribution 230.0 L/kg 230.0 L/kg Average volume of distribution; heart disease; patients; DRUGBANK
Volume of Distribution 2.4 L/kg 2.4 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 11.0 h 10-12 h elimination half-life; normal,healthy; DRUGBANK
Half-life 10.0 h ~10 h elimination half-life; normal,healthy; patients; DRUGBANK
Half-life 18.5 h 18.5 h RD, renal impairment, Renal disease，including uremia; DRUGBANK
Half-life 10.0 h 10 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 730.0 mg/kg 730.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 2.0 % <2 % Faeces excretion; DRUGBANK
Eliminate Route 50.0 % ~50 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Protein Binding 30.0 % ~30 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 20.0 mg/day 20 mg/day PO, oral Zebeta bisoprolol fumarate PDR
Max dose for adults 10.0 mg/day 10 mg/day PO, oral Zebeta bisoprolol fumarate PDR
Max dose for elderly 20.0 mg/day 20 mg/day PO, oral Zebeta bisoprolol fumarate PDR
Max dose for elderly 10.0 mg/day 10 mg/day PO, oral Zebeta bisoprolol fumarate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1