DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00608
Drug Name	Chloroquine
Molecular Weight	319.872
Molecular Formula	C18H26ClN3
CAS Number	54-05-7
SMILES	CCN(CC)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C12
External Links
	DRUGBANK	DB00608
	T3DB	T3D2561
	PubChem Compound	2719
	PDR	3418
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	4.63	-	4.63	-	HANSCH,C ET AL. (1995)
Melting Point	88.25	℃	87-89.5	℃	ChemSpider
pKa	10.1	-	10.1	-	SANGSTER (1994)

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
Bioavailability	77.0	%	52-102	%	Capsule, PO, Oral;		DRUGBANK
Bioavailability	90.5	%	67-114	%	Tablet, PO, oral;		DRUGBANK
Bioavailability	80.0	%	~80	%	PO, oral;		The Pharmacological Basis of Therapeutics
C Max	975.0	ng/ml	650-1300	ug/L	intravenous injection, IV;		DRUGBANK
C Max	96.5	ng/ml	65-128	ug/L	PO, oral;		DRUGBANK
C Max	76.0	ng/ml	76±14	ng/ml	PO, oral;		The Pharmacological Basis of Therapeutics
C Max	268.5	ng/ml	57-480	ng/ml	IM,intramuscular injection;		The Pharmacological Basis of Therapeutics
C Max	837.0	ng/ml	837±248	ng/ml	adults; normal,healthy;		The Pharmacological Basis of Therapeutics
T Max	0.50	h	0.5	h	PO, oral;		DRUGBANK
T Max	3.6	h	3.6±2	h	PO, oral;		The Pharmacological Basis of Therapeutics
T Max	0.25	h	0.25	h	IM,intramuscular injection;		The Pharmacological Basis of Therapeutics
Clearance	0.68	L/h/kg	0.35-1	L/h/kg	Plasma clearance;		DRUGBANK
Clearance	0.50	L/h/kg	3.7-13	ml/min/kg	Average clearance; intravenous injection, IV;		The Pharmacological Basis of Therapeutics
Clearance	0.25	L/h/kg	4.1	ml/min/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	500.0	L/kg	200-800	L/kg			DRUGBANK
Volume of Distribution	196.5	L/kg	132-261	L/kg	Average volume of distribution; intravenous injection, IV;		The Pharmacological Basis of Therapeutics
Volume of Distribution	140.0	L/kg	140	L/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Half-life	960.0	h	20-60	day			DRUGBANK
Half-life	408.0	h	10-24	day	intravenous injection, IV;		The Pharmacological Basis of Therapeutics
Half-life	984.0	h	41±14	day			The Pharmacological Basis of Therapeutics
Half-life	360.0	h	15±6	day	Active metabolite;		The Pharmacological Basis of Therapeutics
Half-life	570.0	h	570	h	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Eliminate Route	50.0	%	50	%	Urinary excretion; Unchanged drug;		DRUGBANK
Eliminate Route	55.0	%	52-58	%	Urinary excretion; intravenous injection, IV; Unchanged drug;		The Pharmacological Basis of Therapeutics
Protein Binding	60.0	%	46-74	%	plasma proteins;		DRUGBANK
Protein Binding	66.6	%	66.6±3.3	%	Optical rotation S;		The Pharmacological Basis of Therapeutics
Protein Binding	42.7	%	42.7±2.1	%	Optical rotation R;	RD, renal impairment, Renal disease，including uremia → ;	The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for infants	16.6	mg/kg	16.6	mg/kg	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for infants	10.0	mg base/kg/dose	10	mg base/kg/dose	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for infants	41.5	mg/kg	41.5	mg/kg	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for infants	25.0	mg/kg base	25	mg/kg base	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for infants	1.18571428571429	mg/kg/day	8.3	mg/kg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for infants	5.0	mg base/kg/week	5	mg base/kg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	16.6	mg/kg	16.6	mg/kg	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	10.0	mg/kg/dose	10	mg base/kg/dose	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	1000.0	mg	1000	mg	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	600.0	mg base	600	mg base	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	41.5	mg/kg	41.5	mg/kg	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	25.0	mg/kg	25	mg/kg base	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	2500.0	mg	2.5	g	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	1500.0	mg base	1.5	g base	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	1.18571428	mg/kg/day	8.3	mg/kg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	0.7142857	mg/kg/day	5	mg base/kg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	71.42857142	mg/day	500	mg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for children	0.14285714	mg/day	300	mg base/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	16.6	mg/kg	16.6	mg/kg	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	10.0	mg base/kg/dose	10	mg base/kg/dose	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	1000.0	mg	1000	mg	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	600.0	mg base	600	mg base	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	41.5	mg/kg	41.5	mg/kg	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	25.0	mg/kg base	25	mg/kg base	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	1250.0	mg/day	2.5	g	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	750.0	mg base/day	1.5	g base	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	1.18571428571429	mg/kg/day	8.3	mg/kg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	0.714285714285714	mg base/kg/day	5	mg base/kg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	71.4285714285714	mg/day	500	mg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adolescents	300.0	mg base/week	300	mg base/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	1000.0	mg/dose	1000	mg/dose	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	600.0	mg base/dose	600	mg base/dose	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	2500.0	mg	2.5	g	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	1.5	g base	1.5	g base	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	71.4285714285714	mg/day	500	mg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	300.0	mg base/week	300	mg base/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	1000.0	mg/day	1000	mg/day	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for adults	600.0	mg base/day	600	mg base/day	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	1000.0	mg/dose	1000	mg/dose	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	600.0	mg base/dose	600	mg base/dose	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	2500.0	mg	2.5	g	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	1.5	g base	1.5	g base	PO, oral; in 48 hours	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	71.4285714285714	mg/day	500	mg/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	300.0	mg base/week	300	mg base/week	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	1000.0	mg/day	1000	mg/day	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR
Max dose for geriatric	600.0	mg base/day	600	mg base/day	PO, oral	Chloroquine Phosphate	chloroquine phosphate	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1