Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00607 ...
Drug Name Nafcillin
Molecular Weight 414.475
Molecular Formula C21H22N2O5S
CAS Number 147-52-4
SMILES [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C1=C(OCC)C=CC2=CC=CC=C12)C(O)=O
External Links
DRUGBANK DB00607
PubChem Compound 8982
PDR 3703
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.3 - 3.3 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 30000.0 ng/ml 30.0 ug/ml intravenous injection, IV; DRUGBANK
T Max 0.0833 h 5 min intravenous injection, IV; DRUGBANK
Metabolic 30.0 % <30 % Liver metabolism; DRUGBANK
Clearance 0.20 L/h/kg 3.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.22 L/kg 0.22 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.78 h 33-61 min elimination half-life; intravenous injection, IV; DRUGBANK
Half-life 0.70 h 0.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 5000.0 mg/kg >5000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1000.0 mg/kg >1000 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Protein Binding 89.9 % 89.9±1.5 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 20.0 mg/kg/day 20 mg/kg/day IM,intramuscular injection Nafcillin nafcillin PDR
Max dose for neonates 200.0 mg/kg/day 200 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for neonates 150.0 mg/kg/day 150 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for neonates 150.0 mg/kg/day 150 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for neonates 100.0 mg/kg/day 100 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for infants 50.0 mg/kg/day 50 mg/kg/day IM,intramuscular injection Nafcillin nafcillin PDR
Max dose for infants 200.0 mg/kg/day 200 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for children 6000.0 mg/day 6 g/day IM,intramuscular injection Nafcillin nafcillin PDR
Max dose for children 200.0 mg/kg/day 200 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for children 50.0 mg/kg/day 50 mg/kg/day IM,intramuscular injection Nafcillin nafcillin PDR
Max dose for children 200.0 mg/kg/day 200 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for children 12000.0 mg/day 12 g/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for adolescents 6000.0 mg/day 6 g/day IM,intramuscular injection Nafcillin nafcillin PDR
Max dose for adolescents 200.0 mg/kg/day 200 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for adolescents 50.0 mg/kg/day 50 mg/kg/day IM,intramuscular injection Nafcillin nafcillin PDR
Max dose for adolescents 200.0 mg/kg/day 200 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for adolescents 12000.0 mg/day 12 g/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for adults 6000.0 mg/day 6 g/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for adults 12000.0 mg/day 12 g/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for geriatric 6000.0 mg/day 6 g/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR
Max dose for geriatric 12000.0 mg/day 12 g/day intravenous injection, IV;IM,intramuscular injection; Nafcillin nafcillin PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1