Basic Information
| Drug ID | DDPD00605 |
|
| Drug Name | Sulindac | |
| Molecular Weight | 356.411 | |
| Molecular Formula | C20H17FO3S | |
| CAS Number | 38194-50-2 | |
| SMILES | CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(C=C1)S(C)=O | |
| External Links | ||
| DRUGBANK | DB00605 | |
| PubChem Compound | 1548887 | |
| PDR | 2967 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.42 | - | 3.42 | - | SANGSTER (1993) |
| Melting Point | 183.0 | ℃ | 183 | ℃ | PhysProp |
| Water Solubility | 3000.0 | mg/L | 3000 | mg/L | MERCK INDEX 1996); pH 7 |
| pKa | 4.7 | - | 4.7 | - | MERCK INDEX (1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 90.0 | % | 90 | % | PO, oral; | DRUGBANK |
| Clearance | 4.1 | L/h | 68.12±27.56 | ml/min | Renal clearance; normal,healthy; adults; | DRUGBANK |
| Half-life | 7.8 | h | 7.8 | h | DRUGBANK | Half-life | 16.4 | h | 16.4 | h | DRUGBANK |
| Toxicity LD50 | 264.0 | mg/kg | 264.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 50.0 | % | ~50 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 93.0 | % | ~93 | % | human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Sulindac | sulindac | PDR |
| Max dose for children | 400.0 | mg/day | 400 | mg/day | PO, oral | Sulindac | sulindac | PDR |
| Max dose for adolescents | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Sulindac | sulindac | PDR |
| Max dose for adolescents | 400.0 | mg/day | 400 | mg/day | PO, oral | Sulindac | sulindac | PDR |
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | PO, oral | Sulindac | sulindac | PDR |
| Max dose for elderly | 400.0 | mg/day | 400 | mg/day | PO, oral | Sulindac | sulindac | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1