Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00603 ...
Drug Name Medroxyprogesterone acetate
Molecular Weight 386.5244
Molecular Formula C24H34O4
CAS Number 71-58-9
SMILES [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C
External Links
DRUGBANK DB00603
T3DB T3D4730
PubChem Compound 6279
PDR 1015
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 207.0 ℃ 205-209 ℃ FDA Approved Drug Products: Medroxyprogesterone Acetate Subcutaneous Injection
Water Solubility 10.0 mM 10 mM Chemspider

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 487.9 ng.h/ml 543.4-1981.1 nmol.h/L PO, oral; DRUGBANK
AUC 756.8 ng.h/ml 81.58±27.64 nmol.day/L IM,intramuscular injection; DRUGBANK
AUC 670.3 ng.h/ml 72.26±38.73 nmol.day/L subcutaneous injection, SC; DRUGBANK
C Max 88.9 ng/ml 145-315 nmol/L PO, oral; DRUGBANK
C Max 40.8 ng/ml 33-178 nmol/L PO, oral; DRUGBANK
C Max 1.8 ng/ml 4.69±1.52 nmol/L IM,intramuscular injection; DRUGBANK
C Max 1.5 ng/ml 3.83±1.56 nmol/L subcutaneous injection, SC; DRUGBANK
T Max 2.0 h 1-3 h PO, oral; DRUGBANK
T Max 2.5 h 1.5-3.5 h PO, oral; DRUGBANK
T Max 114.0 h 4.75±2.09 day IM,intramuscular injection; DRUGBANK
T Max 156.5 h 6.52±2.07 day subcutaneous injection, SC; DRUGBANK
Clearance 0.91 L/h/kg 21.9±4.3 L/kg/day Average clearance; DRUGBANK
Clearance 62.5 L/h 1600-4000 L/day Average clearance; patients; DRUGBANK
Volume of Distribution 20.0 L 20±3 L DRUGBANK
Half-life 0.38 h 15-30 min distribution half-life; PO, oral; DRUGBANK
Half-life 50.0 h 40-60 h elimination half-life; PO, oral; DRUGBANK
Half-life 20.6 h 0.86±0.30 day distribution half-life; IM,intramuscular injection; DRUGBANK
Half-life 576.7 h 24.03±21.74 day elimination half-life; IM,intramuscular injection; DRUGBANK
Half-life 25.2 h 1.05±0.56 day distribution half-life; subcutaneous injection, SC; DRUGBANK
Half-life 741.6 h 30.90±15.11 day elimination half-life; subcutaneous injection, SC; DRUGBANK
Toxicity LD50 6400.0 mg/kg >6400 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 16000.0 mg/kg >16 g/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 900.0 mg/kg >900 mg/kg Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 1500.0 mg/kg >1500 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Toxicity LD50 900.0 mg/kg >900 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity LD50 1500.0 mg/kg >1500 mg/kg subcutaneous injection, SC; mouse; DRUGBANK
Protein Binding 86.0 % 86 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1