Basic Information
| Drug ID | DDPD00599 |
|
| Drug Name | Thiopental | |
| Molecular Weight | 242.338 | |
| Molecular Formula | C11H18N2O2S | |
| CAS Number | 76-75-5 | |
| SMILES | CCCC(C)C1(CC)C(=O)NC(=S)NC1=O | |
| External Links | ||
| DRUGBANK | DB00599 | |
| T3DB | T3D2835 | |
| PubChem Compound | 3000715 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.85 | - | 2.85 | - | HANSCH,C ET AL. (1995) |
| pKa | 7.55 | - | 7.55 | - | SANGSTER (1994) |
| Log S | -3.36 | - | -3.36 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.49 | L/h/kg | 8.2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.2 | L/kg | 1.2 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.5 | h | 3-8 | h | DRUGBANK | Half-life | 2.0 | h | 2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 50.6 | mg/kg | 50.6 | mg/kg | intravenous injection, IV; mouse; | T3DB |
| Protein Binding | 80.0 | % | ~80 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1