Drug ID | DDPD00598 |
|
Drug Name | Labetalol | |
Molecular Weight | 328.4055 | |
Molecular Formula | C19H24N2O3 | |
CAS Number | 36894-69-6 | |
SMILES | CC(CCC1=CC=CC=C1)NCC(O)C1=CC(C(N)=O)=C(O)C=C1 | |
External Links | ||
DRUGBANK | DB00598 | |
T3DB | T3D3517 | |
PubChem Compound | 3869 | |
PDR | 1568 | |
Drugs.com | Drugs.com Drug Page |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
---|---|---|---|---|---|
Boiling Point | 552.7 | ℃ | 552.7 | ℃ | http://www.chemspider.com/Chemical-Structure.3734.html |
Melting Point | 188.0 | ℃ | 188 | ℃ | U.S. Patent 4,012,444. |
pKa | 9.3 | - | 9.3 | - | https://pubchem.ncbi.nlm.nih.gov/compound/Labetalol#section=Caco2-Permeability |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
---|---|---|---|---|---|---|---|
Bioavailability | 48.5 | % | 11-86 | % | PO, oral; Age; food; | Age ↑ ;food ↑ ; | DRUGBANK |
T Max | 0.67 | h | 0.33-1 | h | DRUGBANK | ||
T Max | 2.0 | h | 2 | h | DRUGBANK | ||
Clearance | 90.0 | L/h | ~1500 | ml/min | Plasma clearance; | DRUGBANK | |
Clearance | 66.0 | L/h | 1100.0 | ml/min | Total clearance; | DRUGBANK | |
Clearance | 1.4 | L/h/kg | 23 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
Volume of Distribution | 805.0 | L | 805.0 | L | patients; | DRUGBANK | |
Volume of Distribution | 467.5 | L | 188-747 | L | hypertension; patients; | DRUGBANK | |
Volume of Distribution | 4.8 | L/kg | 4.8 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
Half-life | 3.9 | h | 1.7-6.1 | h | DRUGBANK | ||
Half-life | 4.4 | h | 4.4 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
Toxicity LD50 | 600.0 | mg/kg | 600.0 | mg/kg | PO, oral; mouse; | DRUGBANK | |
Toxicity LD50 | 2000.0 | mg/kg | >2 | g/kg | PO, oral; Rattus, Rat; | DRUGBANK | |
Toxicity LD50 | 55.0 | mg/kg | 50-60 | mg/kg | intravenous injection, IV; mouse; Rattus, Rat; | DRUGBANK | |
Toxicity LD50 | 66.0 | mg/kg | 66.0 | mg/kg | intravenous injection, IV; parenteral administration; Rattus, Rat; | T3DB | |
Eliminate Route | 57.5 | % | 55-60 | % | Urinary excretion; | DRUGBANK | |
Eliminate Route | 19.5 | % | 12-27 | % | Faeces excretion; | DRUGBANK | |
Protein Binding | 50.0 | % | ~50 | % | DRUGBANK |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
---|---|---|---|---|---|---|---|---|
Max dose for children | 1.0 | mg/kg/dose | 1 | mg/kg/dose | intravenous injection, IV | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for children | 40.0 | mg/dose | 40 | mg/dose | intravenous injection, IV | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for children | 72.0 | mg/kg/day | 3 | mg/kg/hour | intravenous infusion, iv in drop | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for adolescents | 1.0 | mg/kg/dose | 1 | mg/kg/dose | intravenous injection, IV | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for adolescents | 40.0 | mg/dose | 40 | mg/dose | intravenous injection, IV | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for adolescents | 0.125 | mg/kg/day | 3 | mg/kg/hour | intravenous infusion, iv in drop | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for adults | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for adults | 300.0 | mg/day | 300 | mg/day | intravenous injection, IV | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for geriatric | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |
Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | intravenous injection, IV | Labetalol Hydrochloride Injection | labetalol hydrochloride | PDR |