Basic Information
| Drug ID | DDPD00585 |
|
| Drug Name | Nizatidine | |
| Molecular Weight | 331.45 | |
| Molecular Formula | C12H21N5O2S2 | |
| CAS Number | 76963-41-2 | |
| SMILES | CNC(NCCSCC1=CSC(CN(C)C)=N1)=C[N+]([O-])=O | |
| External Links | ||
| DRUGBANK | DB00585 | |
| PubChem Compound | 3033637 | |
| PDR | 1460 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.1 | - | 1.1 | - | DRUGBANK |
| Melting Point | 131.0 | ℃ | 130-132 | ℃ | PhysProp |
| Water Solubility | 21.5 | mg/L | 10-33 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 70.0 | % | >70 | % | DRUGBANK | |
| Metabolic | 7.0 | % | <7 | % | Liver metabolism; PO, oral; | DRUGBANK |
| Clearance | 50.0 | L/h | 40-60 | L/h | DRUGBANK | Clearance | 10.5 | L/h | 7.0-14 | L/h | renal insufficiency; patients; | DRUGBANK | Clearance | 0.59 | L/h/kg | 9.8 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.2 | L/kg | 0.8-1.5 | L/kg | DRUGBANK | Volume of Distribution | 1.0 | L/kg | 1 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.5 | h | 1-2 | h | DRUGBANK | Half-life | 1.5 | h | 1.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 301.0 | mg/kg | 301.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Protein Binding | 35.0 | % | 35 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
| Max dose for infants | 15.0 | mg/kg/day | 15 | mg/kg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
| Max dose for infants | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
| Max dose for children | 300.0 | mg/day | 300 | mg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
| Max dose for children | 15.0 | mg/kg/day | 15 | mg/kg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
| Max dose for adolescents | 300.0 | mg/day | 300 | mg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
| Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | PO, oral | Nizatidine Capsules | nizatidine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1