Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00584 ...
Drug Name Enalapril
Molecular Weight 376.4467
Molecular Formula C20H28N2O5
CAS Number 75847-73-3
SMILES CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O
External Links
DRUGBANK DB00584
PubChem Compound 5388962
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -5.64 - -5.64 - ADME Research, USCD
Log P 0.07 - 0.07 - HANSCH,C ET AL. (1995)
Melting Point 143.75 ℃ 143-144.5 ℃ MSDS
Water Solubility 16400.0 mg/L 16400 mg/L MCFARLAND,JW ET AL. 2001)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 40.0 % 40 % PO, oral; DRUGBANK
Bioavailability 41.0 % 41±15 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 69.0 ng/ml 69±37 ng/ml PO, oral; young; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.0 h 1 h PO, oral; DRUGBANK
T Max 3.5 h 3-4 h PO, oral; Active metabolite; DRUGBANK
T Max 3.0 h 3.0±1.6 h PO, oral; young; normal,healthy; The Pharmacological Basis of Therapeutics
Tss 96.0 h 4 day PO, oral; DRUGBANK
Metabolic 60.0 % 60 % DRUGBANK
Clearance 9.5 L/h ~158±47 ml/min Renal clearance; normal,healthy; Male, men; DRUGBANK
Clearance 0.29 L/h/kg 4.9±1.5 ml/min/kg apparent clearance; Oral multiple dose;  Female, women → ;Neonates ↓ ;Children ↑ ;Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;congestive heart disease ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.7 L/kg 1.7±0.7 L/kg Apparent volume of distribution; Oral multiple dose; The Pharmacological Basis of Therapeutics
Half-life 36.5 h 35-38 h terminal half-life; DRUGBANK
Half-life 12.5 h 11-14 h effective half-life; Multiple dose; DRUGBANK
Half-life 11.0 h 11.0 h at steady state; Multiple dose; RD, renal impairment, Renal disease，including uremia ↑ ;Hepatic cirrhosis, cirr ↑ ; The Pharmacological Basis of Therapeutics
Eliminate Route 61.0 % ~61 % Urinary excretion; DRUGBANK
Eliminate Route 33.0 % ~33 % Faeces excretion; DRUGBANK
Eliminate Route 88.0 % 88±7 % Urinary excretion; intravenous injection, IV; Unchanged drug; Hepatitis, Hep → ; The Pharmacological Basis of Therapeutics
Protein Binding 50.0 % <50 % plasma proteins; human, homo sapiens; DRUGBANK
Protein Binding 55.0 % 50-60 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1