DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00582
Drug Name	Voriconazole
Molecular Weight	349.3105
Molecular Formula	C16H14F3N5O
CAS Number	137234-62-9
SMILES	C[C@@H](C1=NC=NC=C1F)[C@](O)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1
External Links
	DRUGBANK	DB00582
	PubChem Compound	71616
	PDR	1815
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	1.0	-	1.0	-	DRUGBANK
Melting Point	128.5	℃	127-130	℃	DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
Bioavailability	96.0	%	96	%			DRUGBANK
Bioavailability	96.0	%	96.0	%	PO, oral;		The Pharmacological Basis of Therapeutics
C Max	2356.0	ng/ml	2356.0	ng/ml	PO, oral;		The Pharmacological Basis of Therapeutics
C Max	3621.0	ng/ml	3621.0	ng/ml	intravenous injection, IV;		The Pharmacological Basis of Therapeutics
T Max	1.1	h	1.1	h	PO, oral;		The Pharmacological Basis of Therapeutics
Clearance	0.23	L/h/kg	3.8	ml/min/kg	at steady state;	hepatopathy，LD ↓ ;	The Pharmacological Basis of Therapeutics
Clearance	0.50	L/h/kg	8.3	ml/min/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	4.6	L/kg	4.6	L/kg			DRUGBANK
Volume of Distribution	1.6	L/kg	1.6	L/kg	at steady state;		The Pharmacological Basis of Therapeutics
Volume of Distribution	2.2	L/kg	2.2	L/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Half-life	6.7	h	6.7	h			The Pharmacological Basis of Therapeutics
Half-life	5.6	h	5.6	h	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Toxicity LDLo	300.0	mg/kg	300.0	mg/kg	PO, oral; mouse; Rattus, Rat;		DRUGBANK
Eliminate Route	2.0	%	<2	%	Urinary excretion; Unchanged drug;		DRUGBANK
Eliminate Route	2.0	%	<2	%	Urinary excretion; Unchanged drug;		The Pharmacological Basis of Therapeutics
Protein Binding	58.0	%	58	%			DRUGBANK
Protein Binding	58.0	%	58	%			The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for neonates	18.0	mg/kg/day	18	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for neonates	8.0	mg/kg/day	8	mg/kg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for infants	18.0	mg/kg/day	18	mg/kg/day	intravenous injection, IV;PO, oral;	VFEND	voriconazole	PDR
Max dose for children	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for children	600.0	mg/day	600	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for children	18.0	mg/kg/day	18	mg/kg/day	intravenous injection, IV;PO, oral;	VFEND	voriconazole	PDR
Max dose for children	700.0	mg/day	700	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for children	18.0	mg/kg/day	18	mg/kg/day	intravenous injection, IV;PO, oral;	VFEND	voriconazole	PDR
Max dose for children	700.0	mg/day	700	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for children	18.0	mg/kg/day	18	mg/kg/day	intravenous injection, IV;PO, oral;	VFEND	voriconazole	PDR
Max dose for adolescents	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for adolescents	600.0	mg/day	600	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for adolescents	300.0	mg/day	300	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for adolescents	600.0	mg/day	600	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	18.0	mg/kg/day	18	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for adolescents	18.0	mg/kg/day	18	mg/kg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	700.0	mg/day	700	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adolescents	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adults	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for adults	600.0	mg/day	600	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adults	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adults	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for adults	300.0	mg/day	300	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for adults	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for geriatric	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for geriatric	600.0	mg/day	600	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for geriatric	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for geriatric	12.0	mg/kg/day	12	mg/kg/day	intravenous injection, IV	VFEND	voriconazole	PDR
Max dose for geriatric	300.0	mg/day	300	mg/day	PO, oral	VFEND	voriconazole	PDR
Max dose for geriatric	800.0	mg/day	800	mg/day	PO, oral	VFEND	voriconazole	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1