Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00577 ...
Drug Name Valaciclovir
Molecular Weight 324.3357
Molecular Formula C13H20N6O4
CAS Number 124832-26-4
SMILES CC(C)[C@H](N)C(=O)OCCOCN1C=NC2=C1NC(N)=NC2=O
External Links
DRUGBANK DB00577
T3DB T3D3542
PubChem Compound 60773
PDR 233
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.3 - -0.3 - https://pubchem.ncbi.nlm.nih.gov/compound/valacyclovir#section=Vapor-Density
Melting Point 171.0 ℃ 170-172 ℃ https://www.chemicalbook.com/ChemicalProductProperty_US_CB8430566.aspx
Water Solubility 174000.0 mg/L 174 mg/ml https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020487s007rel2_lbl.pdf
pKa 1.9 - 1.90,7.47,9.43 - https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020487s007rel2_lbl.pdf
pKa 7.47 - 1.90,7.47,9.43 - https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020487s007rel2_lbl.pdf
pKa 9.43 - 1.90,7.47,9.43 - https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020487s007rel2_lbl.pdf

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 54.5 % 54.5±9.1 % Oral single dose; food; food → ; DRUGBANK
Bioavailability 54.5 % 54.5±9.1 % intravenous injection, IV; food; food → ; DRUGBANK
Bioavailability 54.0 % 54(42-73) % PO, oral; Drug form; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 560.0 ng/ml ≤0.56 mcg/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 4800.0 ng/ml 4.8±1.5 mcg/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.5 h 1.5 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.9 h 1.9±0.6 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 15.3 L/h ~255±86 ml/min normal,healthy; DRUGBANK
Volume of Distribution 1.3 L/kg 1.34±0.65 L/kg immunocompromised; pediatric patients; DRUGBANK
Half-life 2.9 h 2.5-3.3 h elimination half-life; normal renal function; DRUGBANK
Half-life 2.5 h 2.5±0.3 h Metabolite; RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 903.5 mg/kg 903.5 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 46.0 % 46 % Urinary excretion; Oral single dose; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 47.0 % 47 % Faeces excretion; Oral single dose; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 44.0 % 44±10 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 15.7 % 13.5-17.9 % plasma proteins; human, homo sapiens; DRUGBANK
Protein Binding 15.7 % 13.5-17.9 % adults; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics
Protein Binding 27.5 % 22-33 % Metabolite; adults; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 4000.0 mg/day 4 g/day PO, oral Valtrex valacyclovir hydrochloride PDR
Max dose for children 60.0 mg/kg/day 60 mg/kg/day PO, oral Valtrex valacyclovir hydrochloride PDR
Max dose for children 3000.0 mg/day 3 g/day PO, oral Valtrex valacyclovir hydrochloride PDR
Max dose for adolescents 4000.0 mg/day 4 g/day PO, oral Valtrex valacyclovir hydrochloride PDR
Max dose for adults 4000.0 mg/day 4 g/day PO, oral Valtrex valacyclovir hydrochloride PDR
Max dose for geriatric 4000.0 mg/day 4 g/day PO, oral Valtrex valacyclovir hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1