Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00572 ...
Drug Name Atropine
Molecular Weight 289.3694
Molecular Formula C17H23NO3
CAS Number 51-55-8
SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)C1=CC=CC=C1
External Links
DRUGBANK DB00572
PubChem Compound 174174
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.83 - 1.83 - HANSCH,C ET AL. (1995)
Melting Point 118.5 ℃ 118.5 ℃ PhysProp
Water Solubility 2200.0 mg/L 2200 mg/L DEHN,WM 1917)
pKa 9.43 - 9.43 - SANGSTER (1994)
Log S -2.12 - -2.12 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 50.0 % 50.0 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 2.6 ng/ml 2.6±0.5 ng/ml IM,intramuscular injection; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.15 h 0.15±0.04 h IM,intramuscular injection; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Metabolic 31.5 % 13-50 % Urinary excretion; Unchanged drug; DRUGBANK
Clearance 0.48 L/h/kg 8±4 ml/min/kg Elderly ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.46 L/h/kg 7.6 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.0 L/kg 2.0±1.1 L/kg Children ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.3 L/kg 3.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.0 h 3±0.9 h Male, men; DRUGBANK
Half-life 2.3 h 2.3±0.9 h  Female, women; DRUGBANK
Half-life 3.5 h 3.5±1.5 h Children ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 4.1 h 4.1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 75.0 mg/kg 75.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 31.5 % 13-50 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 57.0 % 57±8 % Urinary excretion; Raceme D/L; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 18.0 % 14-22 % plasma proteins; DRUGBANK
Protein Binding 18.0 % 14-22 % Elderly → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1