Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00571 ...
Drug Name Propranolol
Molecular Weight 259.3434
Molecular Formula C16H21NO2
CAS Number 525-66-6
SMILES CC(C)NCC(O)COC1=CC=CC2=C1C=CC=C2
External Links
DRUGBANK DB00571
PubChem Compound 4946
PDR 1400
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -4.58 - -4.58 - ADME Research, USCD
Log P 3.48 - 3.48 - AVDEEF,A (1997)
Melting Point 96.0 ℃ 96 ℃ PhysProp
Water Solubility 61.7 mg/L 61.7 mg/L MCFARLAND,JW ET AL. 2001)
pKa 9.42 - 9.42 - SANGSTER (1994)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 26.0 % 26±10 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 18.0 ng/ml 18±15 ng/ml PO, oral; DRUGBANK
C Max 52.0 ng/ml 52±51 ng/ml PO, oral; DRUGBANK
C Max 121.0 ng/ml 121±98 ng/ml PO, oral; DRUGBANK
C Max 245.0 ng/ml 245±110 ng/ml PO, oral; DRUGBANK
C Max 49.0 ng/ml 49±8 ng/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 37.0 ng/ml 37±9 ng/ml Oral single dose; Active metabolite; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2(1-4) h PO, oral; fasting; DRUGBANK
T Max 1.5 h 1.5 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.0 h 1.0 h Oral single dose; Active metabolite; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 3.0 L/h/kg 2.7-3.3 L/h/kg Infants; normal BMI ↓ ; DRUGBANK
Clearance 48.6 L/h 810.0 ml/min hypertension; adults; DRUGBANK
Clearance 0.96 L/h/kg 16±5 ml/min/kg  Female, women ↓ ;Elderly → ;Hepatitis, Hep ↓ ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia → ;Obesity ↓ ;hyperthyroid, HTh ↑ ;Somking ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.72 L/h/kg 12 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 4.0 L/kg 4.0 L/kg DRUGBANK
Volume of Distribution 4.3 L/kg 4.3±0.6 L/kg  Female, women → ;Elderly → ;Preg, pregnant → ;Hepatitis, Hep ↑ ;Hepatic cirrhosis, cirr ↑ ;hyperthyroid, HTh ↑ ;Crohn ↓ ;RD, renal impairment, Renal disease，including uremia → ;Obesity → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.1 L/kg 3.1 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 8.0 h ~8 h elimination half-life; DRUGBANK
Half-life 4.5 h 3-6 h elimination half-life; DRUGBANK
Half-life 3.9 h 3.9±0.4 h  Female, women ↓ ;Preg, pregnant → ;Hepatitis, Hep ↓ ;Hepatic cirrhosis, cirr ↓ ;Obesity ↓ ;RD, renal impairment, Renal disease，including uremia → ;Age → ;Somking → ; The Pharmacological Basis of Therapeutics
Half-life 3.4 h 3.4 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 91.0 % 91 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 0.50 % <0.5 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 90.0 % ~90 % DRUGBANK
Protein Binding 87.0 % 87±6 % Preg, pregnant ↑ ; Female, women → ;Elderly → ;inflammation ↑ ;Crohn ↑ ;Obesity ↑ ;RD, renal impairment, Renal disease，including uremia → ;Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 16.0 mg/kg/day 16 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for neonates 60.0 mg/day 60 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for neonates 0.15 mg/kg/dose 0.15 mg/kg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for neonates 1.0 mg/dose 1 mg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for neonates 3.5 mg/kg/dose 3.5 mg/kg/dose PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for neonates 0.12 mg/kg/dose 0.12 mg/kg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for infants 3.4 mg/kg/day 3.4 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for infants 16.0 mg/kg/day 16 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for infants 60.0 mg/day 60 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for infants 0.15 mg/kg/dose 0.15 mg/kg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for infants 1.0 mg/dose 1 mg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for infants 3.5 mg/kg/dose 3.5 mg/kg/dose PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for infants 15.0 mg/kg/day 15 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 60.0 mg/day 60 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 0.25 mg/kg/dose 0.25 mg/kg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 3.0 mg/dose 3 mg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 8.0 mg/kg/day 8 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 640.0 mg/day 640 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 120.0 mg/day 120 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 15.0 mg/kg/day 15 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 60.0 mg/day 60 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 0.25 mg/kg/dose 0.25 mg/kg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 3.0 mg/dose 3 mg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 8.0 mg/kg/day 8 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 640.0 mg/day 640 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 60.0 mg/day 60 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for children 15.0 mg/kg/day 15 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 60.0 mg/day 60 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 120.0 mg/day 120 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 0.25 mg/kg/dose 0.25 mg/kg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 3.0 mg/dose 3 mg/dose intravenous injection, IV Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 8.0 mg/kg/day 8 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 640.0 mg/day 640 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 120.0 mg/day 120 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adolescents 4.0 mg/kg/day 4 mg/kg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adults 160.0 mg/day 160 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adults 240.0 mg/day 240 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adults 320.0 mg/day 320 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for adults 640.0 mg/day 640 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for geriatric 160.0 mg/day 160 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for geriatric 240.0 mg/day 240 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for geriatric 320.0 mg/day 320 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR
Max dose for geriatric 640.0 mg/day 640 mg/day PO, oral Propranolol Hydrochloride Tablets propranolol hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1