Basic Information
| Drug ID | DDPD00570 |
|
| Drug Name | Vinblastine | |
| Molecular Weight | 810.9741 | |
| Molecular Formula | C46H58N4O9 | |
| CAS Number | 865-21-4 | |
| SMILES | [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]2(O)C(=O)OC)[C@@]13[H])[C@]1(C[C@@]2([H])CN(C[C@](O)(CC)C2)CCC2=C1NC1=C2C=CC=C1)C(=O)OC | |
| External Links | ||
| DRUGBANK | DB00570 | |
| T3DB | T3D4017 | |
| PubChem Compound | 13342 | |
| PDR | 806 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.7 | - | 3.7 | - | SANGSTER (1994) |
| Melting Point | 267.0 | ℃ | 267 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.19 | L/h/kg | 3.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 28.0 | L/kg | 28 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.58 | h | 35 | min | distribution half-life; | DRUGBANK | Half-life | 0.88 | h | 53 | min | elimination half-life; | DRUGBANK | Half-life | 19.0 | h | 19 | h | terminal half-life; | DRUGBANK | Half-life | 67.0 | h | 67 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 423.0 | mg/kg | 423.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 305.0 | mg/kg | 305.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 423.0 | mg/kg | 423.0 | mg/kg | PO, oral; mouse; | T3DB | Toxicity LD50 | 305.0 | mg/kg | 305.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Protein Binding | 98.5 | % | 98-99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for children | 12.5 | mg/m2/day | 12.5 | mg/m2/day | intravenous injection, IV | qw | Vinblastine Sulfate | vinblastine sulfate | PDR |
| Max dose for adolescents | 12.5 | mg/m2/day | 12.5 | mg/m2/day | intravenous injection, IV | qw | Vinblastine Sulfate | vinblastine sulfate | PDR |
| Max dose for adults | 18.5 | mg/m2 | 18.5 | mg/m2 | intravenous injection, IV | q2w | Vinblastine Sulfate | vinblastine sulfate | PDR |
| Max dose for elderly | 18.5 | mg/m2 | 18.5 | mg/m2 | intravenous injection, IV | q2w | Vinblastine Sulfate | vinblastine sulfate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1