Basic Information
| Drug ID | DDPD00569 |
|
| Drug Name | Fondaparinux | |
| Molecular Weight | 1508.263 | |
| Molecular Formula | C31H53N3O49S8 | |
| CAS Number | 104993-28-4 | |
| SMILES | CO[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS(O)(=O)=O)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@H]5O[C@H](COS(O)(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS(O)(=O)=O)[C@H](O)[C@H]4O)C(O)=O)[C@H](OS(O)(=O)=O)[C@H]3NS(O)(=O)=O)[C@H](O)[C@H]2OS(O)(=O)=O)C(O)=O)[C@H](O)[C@H]1NS(O)(=O)=O | |
| External Links | ||
| DRUGBANK | DB00569 | |
| PubChem Compound | 49852292 | |
| PDR | 170 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.4 | - | 0.4 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 100.0 | % | 100 | % | subcutaneous injection, SC; | DRUGBANK |
| Metabolic | 0 | % | 0 | % | DRUGBANK | |
| Clearance | 0.004200 | L/h/kg | 0.07 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 9.0 | L | 7.0-11 | L | normal,healthy; adults; | DRUGBANK |
| Half-life | 19.0 | h | 17-21 | h | DRUGBANK | Half-life | 19.3 | h | 19.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 94.0 | % | 94 | % | high protein binding; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 2.5 | mg/day | 2.5 | mg/day | subcutaneous injection, SC | Arixtra | fondaparinux sodium | PDR |
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | subcutaneous injection, SC | Arixtra | fondaparinux sodium | PDR |
| Max dose for geriatric | 2.5 | mg/day | 2.5 | mg/day | subcutaneous injection, SC | Arixtra | fondaparinux sodium | PDR |
| Max dose for geriatric | 10.0 | mg/day | 10 | mg/day | subcutaneous injection, SC | Arixtra | fondaparinux sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1