Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00567 ...
Drug Name Cephalexin
Molecular Weight 347.389
Molecular Formula C16H17N3O4S
CAS Number 15686-71-2
SMILES [H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(O)=O
External Links
DRUGBANK DB00567
PubChem Compound 27447
PDR 1565
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.65 - 0.65 - HANSCH,C ET AL. (1995)
Boiling Point 727.4 ℃ 727.4 ℃ http://www.chemspider.com/Chemical-Structure.25541.html
Melting Point 326.8 ℃ 326.8 ℃ http://www.chemspider.com/Chemical-Structure.25541.html
Water Solubility 10000.0 mg/L 10 mg/ml http://www.chemspider.com/Chemical-Structure.25541.html

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 100.0 % 100 % PO, oral; DRUGBANK
Bioavailability 90.0 % 90±9 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 7700.0 ng/ml 7.7 mcg/ml DRUGBANK
C Max 12300.0 ng/ml 12.3 mcg/ml DRUGBANK
C Max 28000.0 ng/ml 28±6.4 mcg/ml Oral single dose; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.4 h 1.4±0.8 h Oral single dose; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Metabolic 0 % 0 % DRUGBANK
Clearance 22.6 L/h 376.0 ml/min DRUGBANK
Clearance 0.26 L/h/kg 4.3±1.1 ml/min/kg normal,healthy; adults; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.23 L/h/kg 3.9 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 5.5 L 5.2-5.8 L DRUGBANK
Volume of Distribution 0.26 L/kg 0.26±0.03 L/kg normal,healthy; adults; RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.21 L/kg 0.21 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.83 h 49.5 min fasting; DRUGBANK
Half-life 1.3 h 76.5 min food; DRUGBANK
Half-life 0.90 h 0.90±0.18 h RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 0.57 h 0.57 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 90.0 % >90 % Urinary excretion; DRUGBANK
Eliminate Route 91.0 % 91±18 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 12.5 % 10-15 % DRUGBANK
Protein Binding 14.0 % 14±3 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 15.0 mg/kg/day 15 mg/kg/day PO, oral Keflex cephalexin PDR
Max dose for infants 100.0 mg/kg/day 100 mg/kg/day PO, oral Keflex cephalexin PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day PO, oral Keflex cephalexin PDR
Max dose for children 4000.0 mg/day 4 g/day PO, oral Keflex cephalexin PDR
Max dose for adolescents 100.0 mg/kg/day 100 mg/kg/day PO, oral Keflex cephalexin PDR
Max dose for adolescents 4000.0 mg/day 4 g/day PO, oral Keflex cephalexin PDR
Max dose for adults 4000.0 mg/day 4 g/day PO, oral Keflex cephalexin PDR
Max dose for geriatric 4000.0 mg/day 4 g/day PO, oral Keflex cephalexin PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1